Abstract
To determine clinical outcomes in patients with stage IA polyp-limited versus endometrium-limited high-grade (type II) endometrial carcinoma (EC). We identified all cases of stage IA polyp-limited or endometrium-limited high-grade EC (FIGO grade 3 endometrioid, serous, clear cell, or mixed) who underwent simple hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings, omental biopsy, and pelvic and para-aortic lymph node dissection and received adjuvant treatment at our institution from October 1995 to November 2012. Progression-free survival (PFS) and overall survival (OS) by histology, adjuvant therapy, and polyp-limited versus endometrium-limited disease status were determined using log-rank test. We analyzed 3 treatment groups: patients who received chemotherapy with or without radiation therapy (RT) (intravaginal or pelvic); patients who received RT (intravaginal RT or pelvic RT) alone; and patients who received no adjuvant treatment. In all, 85 women underwent hysterectomy/salpingo-oophorectomy; all were surgically staged with lymph node assessment and had stage IA EC with no lymphovascular or myometrial invasion. Median follow-up for survivors was 46.5 months (range, 1.98-188.8 months). Forty-nine patients (57....Continue Reading
References
May 3, 2000·Lancet·C L CreutzbergM van Lent
Sep 26, 2001·Cancer·I CohenY Beyth
Feb 27, 2004·Gynecologic Oncology·Henry M KeysUNKNOWN Gynecologic Oncology Group
Jul 12, 2005·Gynecologic Oncology·Michael G KellyPeter E Schwartz
Dec 3, 2005·Cancer Research·Katsutoshi OdaFrank McCormick
Dec 17, 2005·Current Opinion in Oncology·Yardena Samuels, Kajsa Ericson
Dec 17, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Nisha BansalRobert M Wenham
Mar 9, 2010·Lancet·R A NoutUNKNOWN PORTEC Study Group
Apr 12, 2011·Cancer Research·Mary E UrickDaphne W Bell
Aug 2, 2012·Gynecologic Oncology·Ana P KiessKaled M Alektiar
Sep 11, 2012·Journal of the National Cancer Institute·Anthony KongTheresa A Lawrie
Jan 17, 2013·Gynecologic Oncology·M M LeitaoN R Abu-Rustum
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Oct 19, 2013·Gynecologic Oncology·Christine N Chang-HalpennyJulie Hwang-Graziano
Nov 14, 2013·Gynecologic Oncology·Louis J M van der PuttenJanice S Kwon
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Citations
Feb 9, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Chensi OuyangJune Y Hou
Jul 19, 2019·American Journal of Clinical Pathology·Wenhui LiYalan Bi
Jan 18, 2020·Cancer Chemotherapy and Pharmacology·César Gómez-RaposoEnrique Casado Saenz
Jul 18, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisNawar A Latif
Apr 12, 2019·American Journal of Clinical Oncology·Vincenzo D MandatoGiovanni B La Sala