An Assessment of Prognostic Factors, Adjuvant Treatment, and Outcomes of Stage IA Polyp-Limited Versus Endometrium-Limited Type II Endometrial Carcinoma

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Lusha W LiangVicky Makker

Abstract

To determine clinical outcomes in patients with stage IA polyp-limited versus endometrium-limited high-grade (type II) endometrial carcinoma (EC). We identified all cases of stage IA polyp-limited or endometrium-limited high-grade EC (FIGO grade 3 endometrioid, serous, clear cell, or mixed) who underwent simple hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings, omental biopsy, and pelvic and para-aortic lymph node dissection and received adjuvant treatment at our institution from October 1995 to November 2012. Progression-free survival (PFS) and overall survival (OS) by histology, adjuvant therapy, and polyp-limited versus endometrium-limited disease status were determined using log-rank test. We analyzed 3 treatment groups: patients who received chemotherapy with or without radiation therapy (RT) (intravaginal or pelvic); patients who received RT (intravaginal RT or pelvic RT) alone; and patients who received no adjuvant treatment. In all, 85 women underwent hysterectomy/salpingo-oophorectomy; all were surgically staged with lymph node assessment and had stage IA EC with no lymphovascular or myometrial invasion. Median follow-up for survivors was 46.5 months (range, 1.98-188.8 months). Forty-nine patients (57....Continue Reading

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Citations

Feb 9, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Chensi OuyangJune Y Hou
Jul 19, 2019·American Journal of Clinical Pathology·Wenhui LiYalan Bi
Jan 18, 2020·Cancer Chemotherapy and Pharmacology·César Gómez-RaposoEnrique Casado Saenz
Jul 18, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dimitrios NasioudisNawar A Latif
Apr 12, 2019·American Journal of Clinical Oncology·Vincenzo D MandatoGiovanni B La Sala

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