PMID: 15342982Sep 3, 2004Paper

An assessment of published pediatric dosage guidelines for enoxaparin: a retrospective review

Journal of Pediatric Hematology/oncology
Sharon H HoLouis D Wadsworth

Abstract

To evaluate the ability of published dosage guidelines for enoxaparin to achieve therapeutic anticoagulation and to determine whether the routine monitoring of anti-Xa levels is still necessary at a tertiary care pediatric institution. Consecutive charts and laboratory records were reviewed for all patients receiving treatment doses of enoxaparin for thrombosis in the authors institution over a 4-year period (1998-2002). Sixty-six percent (25/38) of the anti-Xa levels were within the recommended therapeutic range (0.5-1.0 [+/- 10%] U/mL) after two doses. The success rates of achieving therapeutic levels were 1/6, 2/3, 6/9, 10/11, and 6/9, for patients 2 months or younger, more than 2 months to 1 year, more than 1 year to 6 years, more than 6 years to 12 years, and more than 12 years of age, respectively. Patients with cardiac or renal disease were more likely to achieve high anti-Xa levels. Thirty-seven percent of patients reported adverse effects. The most common effects were injection site-related bruising and minor bleeding. One patient experienced a major bleed that was not life-threatening. Most patients achieved therapeutic anticoagulation when dosed according to the published guidelines. Children with cardiac conditions ...Continue Reading

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Citations

Jun 8, 2007·Intensive Care Medicine·Joe BontadelliManuela Albisetti
Jun 26, 2013·Clinical Pharmacokinetics·Donald L YeeGuy Young
Mar 5, 2010·Cardiology in the Young·Joan Sanchez de ToledoConstantinos Chrysostomou
Feb 16, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sirak PetrosLothar Engelmann
Jul 22, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Katerina TousovskaJaroslav Sterba
Mar 22, 2006·Acta Haematologica·Nick MerkelRosemarie Schobess
Sep 3, 2013·Thrombosis Research·Marion K MateosRichard J Cohn
Aug 29, 2007·Pharmacotherapy·Janet I MalowanyDavid S C Lee
Mar 30, 2010·British Journal of Haematology·Vera IgnjatovicPaul Monagle
Oct 8, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Brady S MoffettJun Teruya
Sep 25, 2017·Therapeutic Drug Monitoring·Brady S MoffettDonald L Yee
Mar 13, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ankush ChanderUNKNOWN Thrombosis and Hemostasis in Newborns (THiN) Group
Oct 1, 2017·The Annals of Pharmacotherapy·Brady S MoffettDonald Yee
Jan 4, 2012·Acta Paediatrica·Mirjana Lulic-BoticaGirija Natarajan
Mar 6, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Therese M GigliaJonathan W Byrnes
Jan 30, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Marcio M Andrade-CamposDaniel Rubio-Felix
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Apr 26, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Christine Nguyen DinhDonald Mahoney
Jul 31, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Angela WolseyCollin R Anderson
Apr 11, 2015·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Elizabeth W McCormickJill A Morgan
Jun 9, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·James TingUNKNOWN Thrombosis and Hemostasis in Newborns (THiN) Group

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