An assessment of the cytotoxic effects of graphene nanoparticles on the epithelial cells of the human lung

Toxicology and Industrial Health
Nafiseh NasirzadehYousef Mohammadian

Abstract

Nanomaterials are widely used nowadays in a range of technological and biomedical fields. Graphene as a nanomaterial used in the health-care sector and in workplaces has raised some concerns about its toxicity. This study aimed to evaluate the cytotoxicity of graphene nanoparticles (GNPs) on the A549 epithelial cells of the human lung. The GNPs were synthesized from graphite by the modified Hummer method. The physicochemical characteristics of GNPs were identified by the transmission electron microscope, the scanning electron microscope, and the Brunauer-Emmett-Teller method. The hydrodynamic size of GNPs in the dispersion media was examined using the dynamic light scattering technique. The GNPs were dispersed, after which the A549 cells were cultured. Finally, the cell viability was assayed by the MTT assay. The statistical analysis of variance was used to describe the relationship between the concentration/time variables and the GNP-induced cell deaths. The probit regression model was also used to achieve toxicological indicators. The results showed that the toxicological effects of GNPs on the A549 epithelial cells of the human lung are dose- and time-dependent. The GNPs were more cytotoxic after a 72-h exposure period compa...Continue Reading

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Citations

Apr 3, 2020·Archives of Toxicology·Feng XiaoliShao Longquan
Sep 9, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Trupti N PatelPriyanjali Bhattacharya
Mar 18, 2019·Environmental Science and Pollution Research International·Mansour Rezazadeh AzariAthena Rafieepour
Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Feb 3, 2021·Colloids and Surfaces. B, Biointerfaces·Guihua CaoJianbin Guo
Feb 11, 2021·Nanomaterials·Pietro BelletFrancesco Filippini
Apr 21, 2021·Colloids and Surfaces. B, Biointerfaces·Tais Monteiro MagneRalph Santos-Oliveira
Aug 18, 2021·Toxicology and Industrial Health·Yousef Mohammadian, Nafiseh Nasirzadeh

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Methods Mentioned

BETA
biosensor
in vitro methods
dynamic light scattering
scanning electron microscopy
transmission electron microscopy

Software Mentioned

Minitab

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