An assessment of the genetic diversity of Leishmania infantum isolates from infected dogs in Brazil.

The American Journal of Tropical Medicine and Hygiene
Luís Fábio da S BatistaPatrícia S T Veras

Abstract

Correlations between the genetic diversity of Leishmania infantum (syn. L. chagasi) isolates and their respective geographic origins support the theoretic assumption that visceral leishmaniasis probably originated in the Old World. Because dogs are widely considered to be the main reservoir of this disease, the present study aimed to investigate the degree of genetic divergence among 44 leishmanial canine isolates from two Brazilian cities, Jequié and Campo Grande, located approximately 2,028 km from each other. We hypothesized that a low degree of genetic divergence would be observed among these isolates. In fact, statistical analyses found no significant differences between the isolates using both random amplified polymorphic DNA and multilocus microsatellite typing genotyping techniques with three and seven markers, respectively. These findings provide support for the recent introduction of L. infantum into the New World.

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Citations

Jul 31, 2014·PloS One·Manuela da Silva SolcàPatrícia Sampaio Tavares Veras
Apr 25, 2006·The Journal of Parasitology·Abedelmajeed NasereddinZiad Abdeen
Apr 28, 2016·BioMed Research International·Paulo Eduardo Martins RibollaDiego Peres Alonso
Apr 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chun-Ying ZhangYing Ma
May 8, 2015·Cell Stress & Chaperones·Antje HombachJoachim Clos
Feb 25, 2017·Transboundary and Emerging Diseases·M B de RezendeC E de Oliveira
Mar 23, 2018·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ramon Vieira NunesEduardo Sérgio da Silva

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