An assessment of the isoniazid preventive therapy programme for children in a busy primary healthcare clinic in Nelson Mandela Bay Health District, Eastern Cape Province, South Africa

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
F BlackJ Shea

Abstract

Tuberculosis (TB) is a significant contributor to the international and national burden of disease. Global estimates suggest that there were 10.4 million new cases of TB in 2015. Children accounted for ~10% of these cases, although in South Africa (SA) this figure is thought to be higher. Despite clear evidence that isoniazid preventive therapy (IPT) can reduce the risk of progression from TB infection to disease in TB contacts, IPT has been poorly implemented in SA national TB control programmes. To determine current practices regarding the identification and management of child contacts (<5 years of age) at a primary care clinic in the Nelson Mandela Bay Health District, Eastern Cape Province, SA. A cross-sectional descriptive study was conducted using a retrospective record review of infectious TB index patients aged ≥15 years. Folders of index patients with bacteriologically confirmed pulmonary TB, who started TB treatment between 21 October 2011 and 28 February 2014, were included. A sample size of 246 child contacts was required to obtain adequate power. A 95% confidence interval (CI) was used to determine statistically significant results. Index patient records (N=491) were assessed and 261 child contacts identified. ...Continue Reading

Citations

Mar 5, 2020·African Journal of Primary Health Care & Family Medicine·Blandine B IlungaJannie F Hugo
Dec 31, 2019·Tuberculosis Research and Treatment·Thanduxolo Elford FanaLizo Sotana
May 9, 2021·Infectious Diseases of Poverty·Roberto Zegarra-ChapoñanJhon Zeladita-Huaman
Sep 18, 2021·Paediatrics and International Child Health·E Van GinderdeurenA Van Rie

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