PMID: 9185089Jun 1, 1997Paper

An assessment of the peripheral antinociceptive potential of remoxipride, clonidine and fentanyl in sheep using the forelimb tourniquet

Journal of Veterinary Pharmacology and Therapeutics
D C MainA Jones

Abstract

A modification of the intravenous regional anaesthesia technique was used to assess the peripheral antinociceptive effect of remoxipride, clonidine and fentanyl. Drugs administered intravenously via peripheral catheters were restricted to the distal limb and nociceptive threshold test site by prior inflation of a tourniquet proximal to both the catheter and a threshold-testing device. Lignocaine (1 mg/kg) induced peripheral antinociception during tourniquet inflation. Clonidine (6 micrograms/kg) only induced significant elevations in thresholds after tourniquet deflation. A low dose of remoxipride (2 mg/kg), which had no systemic antinociceptive effect, produced antinociception after its restriction to the periphery. Peripheral administration of saline and tourniquet-induced restriction of blood flow to the distal limb did not alter threshold values. Peripheral administration of fentanyl was used to test a further modification of the injection protocol designed to reduce the incidence of leakage into the systemic circulation. Fentanyl administration (11.2 micrograms/kg) failed to elicit an increase in thresholds when it was restricted to the distal limb test site. The contribution of a peripheral mechanism to the antinociceptio...Continue Reading

References

Jan 1, 1992·Life Sciences·J L Junien, J G Wettstein
Oct 1, 1992·Anesthesia and Analgesia·W Y Abdulla, N M Fadhil
May 1, 1992·Anesthesia and Analgesia·D M GaumannP Jirounek
Apr 1, 1991·Anaesthesia·P ArmstrongJ A Wildsmith
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Oct 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·D C MainI C Kilpatrick
Dec 20, 1995·European Journal of Pharmacology·D C MainI C Kilpatrick

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