An association between an antibody against Chlamydia pneumoniae and common carotid atherosclerosis

Internal Medicine
R KawamotoI Konishi

Abstract

Chlamydia pneumoniae (C. pneumoniae) is an important pathogen for infections of the respiratory tract, and there are recently also a number of reports suggesting its relation with atherosclerosis. This study was performed to clarify the relation between C. pneumoniae infection and sclerotic lesions of the common carotid arteries. We evaluated sclerotic lesions of common carotid arteries by ultrasonography in 147 in-patients (mean age, 70 years; 95% confidence interval, 68-72) in the internal medicine ward, and studied the relation of the known risk factors for atherosclerosis including C. pneumoniae infection. An ultrasonograph and 7.5 MHz linear type B-mode probe were used by a specialist to evaluate sclerotic lesions of common carotid arteries. C. pneumoniae infection was determined by measuring anti-C. pneumoniae IgG specific antibody level (IgG index) using enzyme-linked immunosorbent assay (ELISA) method with serum of fasting blood, which had been preserved at -70 degrees C. IgG index (p=0.0263), from multiple regression analysis using various risk factors as explanatory variables, was a significant independent contributing factor (R2=0.3465, p<0.0001) along with known risk factors such as male (p=0.0289), age (p=0.0007), ...Continue Reading

Citations

Jan 18, 2006·Internal Medicine·Ryuichi KawamotoAtsushi Kamitani
Dec 16, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Babak S JahromiBrian Chiu
Feb 25, 2009·The Journal of Headache and Pain·QiHong LuHongYan Liu
Nov 1, 2002·Journal of Atherosclerosis and Thrombosis·Ryuichi KawamotoYaemi Takagi
Aug 16, 2006·Journal of Atherosclerosis and Thrombosis·Ryuichi KawamotoAtsushi Kamitani
Dec 15, 2005·The Journal of Infection·P HalfonP Cacoub
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J Gil MadreR Fernandez Cenjor
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Amy S MajorMacRae F Linton

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