Oct 12, 2010

An association between immunosenescence and CD4(+)CD25(+) regulatory T cells: a systematic review

Biomedical and Environmental Sciences : BES
Ling WangJie Li

Abstract

Age-related increment of the prevalence of CD4(+)CD25(+) regulatory T (Treg) cells were described controversially, and whether such changes explain immune dysfunction in the elderly is still unclear. The aim of this systematic review is to evaluate the role of the Tregs in immunosenescence. Medline and manual searches were performed to identify all published epidemiological and animal studies investigating the efficacy of the association between immunosenescence and Treg cells. It was founded that the frequency, phenotypic characteristics, and number/function of Tregs were altered significantly with aging. Medical conditions in individuals with advanced ageas well as apoptosis intensity of Treg cells had an impact on the accumulation of Tregs which in turn could deteriorate cytotoxic activity of CD8(+) T and NK cells and production of IL-2. The range of immune cells that could be suppressed by Treg cells was quite wide and covered CD4(+)CD25(+) T cells, NK cells, dendritic cells and even monocytes. These changes were observed both in humans and experimental animals. Besides, it was believed that frequency of Tregs increased with age and was accompanied by intensified suppressive activity for Tregs in patients, for example, with...Continue Reading

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  • Citations22

References

Mentioned in this Paper

Immune Response
T-Lymphocyte
CD4 Antigens
Immune System Diseases
Interleukin 2 Receptor, Alpha
Senility
Alzheimer's Disease
ISG20 gene
Apoptosis
Monocytes as Percentage of Blood Leukocytes (Lab Test)

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