PMID: 8949648Sep 1, 1996Paper

An association between maternal diet and colonic diverticulosis in an animal model

Gut
L WessA Miller

Abstract

Maternal diet may have an effect on the health of the offspring in middle and later life. This study used the laboratory rat as an animal model to examine whether the fibre content of the maternal diet during pregnancy affected subsequent development of colonic diverticula in the offspring fed lifelong fibre deficient or higher fibre diets. The parents of experimental animals were fed either a diet that was known to predispose to colonic diverticulosis or a control diet for one month prior to mating. The offspring were fed one of these diets for 18 months. The incidence of colonic diverticulosis, submucosal collagen content, collagen solubility in weak acid, and the composition of intestinal contents were then measured. Offspring of rats fed a higher fibre diet from higher fibre diet fed parents had 0% incidence of colonic diverticulosis. When offspring (regardless of parental diet) were fed a low fibre diet for life the acid solubility was lowered compared with rats fed lifelong higher fibre diet mean (SD) (0.044 (0.0007) v 0.073 (0.0015) sigmoid colon (ratio of soluble:insoluble collagen)); 21.1% had diverticulosis and there was reduced fibre fermentation. However, when the diet of the parents of the fibre deficient diet fed ...Continue Reading

References

Mar 1, 1975·Australasian Radiology·T K Mow, N K Kwi
Nov 1, 1992·The British Journal of Nutrition·E F ArmstrongC C Macintyre
Feb 1, 1992·Journal of Epidemiology and Community Health·D J Barker, C N Martyn
Dec 1, 1991·Archives of Disease in Childhood·S E Balmer, B A Wharton
Sep 1, 1989·Journal of Epidemiology and Community Health·D J BarkerC M Law
Dec 1, 1989·Archives of Disease in Childhood·S E BalmerB A Wharton
Nov 1, 1985·The American Journal of Clinical Nutrition·N FisherJ Hardy
Oct 1, 1973·Biochemical and Biophysical Research Communications·N R Davis
May 1, 1967·Analytical Biochemistry·K I KivirikkoD J Prockop
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V M MonnierA Cerami
May 1, 1994·Acta Paediatrica·C A EdwardsB A Wharton

❮ Previous
Next ❯

Citations

Apr 26, 2002·The British Journal of Surgery·J SimpsonR C Spiller
May 13, 2003·The Proceedings of the Nutrition Society·Martin Eastwood
Sep 1, 1996·Gut·J H Cummings
Jul 14, 2005·Annual Review of Nutrition·Martin Eastwood, David Kritchevsky
May 27, 2009·World Journal of Gastroenterology : WJG·Daniel Martin CommaneMike Bradburn
May 11, 2012·Digestive Diseases·Martina Böttner, Thilo Wedel
Feb 25, 2006·Digestion·Adolfo Parra-Blanco
Jun 27, 2008·Journal of Clinical Gastroenterology·Sergio MoriniSalvatore M A Campo
May 4, 2006·Alimentary Pharmacology & Therapeutics·L PetruzzielloG Costamagna
Jul 23, 2004·The Journal of Small Animal Practice·R R O M van de SandtJ Kirpensteijn
May 16, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaomei GuoGhassan S Kassab
Oct 17, 2003·World Journal of Gastroenterology : WJG·Gabrio BassottiAntonio Morelli
Apr 22, 2018·Digestive Diseases and Sciences·Bhavesh PatelGhassan S Kassab
Mar 16, 2021·Seminars in Colon & Rectal Surgery·Lillias Maguire

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.