An association between mesial temporal lobe epilepsy with hippocampal sclerosis and human leukocyte antigens

Epilepsia
Cigdem OzkaraCengiz Kuday

Abstract

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is one of the medically intractable epilepsies that may be remediable with surgery. Although the pathogenesis of HS still remains obscure, genetics may play a role as a predisposing factor, with the genetically controlled immune system as one of its aspects. Our aim in this study was to investigate whether there is any association between human leukocyte antigens (HLAs) that are related to chromosome 6 and this specific type of epilepsy. HLA class I and II typing were performed with the microlymphocytotoxicity method on 65 Turkish patients with MTLE-HS and on 184 healthy controls. Our study revealed a significantly high frequency of class II antigens HLA-DQ2, -DR4, and -DR7 alleles and the combination of HLA-DR4-DQ2, and DR7-DQ2 alleles. The HLA alleles that occur with increased frequency in many HLA- associated conditions appear to serve as risk factors that increase susceptibility but are not essential for disease expression. Our data support the role of genetic factors in the development of HS, possibly related to early childhood events that may act as a trigger factor to initiate the cascade in genetically prone patients with specific HLA types to give rise ...Continue Reading

References

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Citations

Jan 22, 2003·Brain & Development·Orvar Eeg-Olofsson
Sep 26, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hong WangJinjie Liu
Feb 11, 2005·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·An D BilliauLieven G Lagae
Jan 24, 2006·Lancet Neurology·Cassandra E I SzoekeLes J Sheffield
Nov 1, 2003·Expert Review of Neurotherapeutics·Craig Watson
Jul 31, 2007·Surgical Neurology·Galip Zihni SanusMehmet Yasar Kaynar
Oct 5, 2010·Pharmacological Reports : PR·Radosław ZarczukKinga K Borowicz
Apr 11, 2017·Journal of Neuropathology and Experimental Neurology·Jian-Qiang LuDonald W Gross
Jul 5, 2017·The International Journal of Neuroscience·Bárbara LealAntónio Martins da Silva

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