An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia

Schizophrenia Research
Georg WintererD R Weinberger

Abstract

Previous studies have suggested that schizophrenic patients show resting changes such as frequency-slowing and decreased coherence in the frontal and temporal area. We sought to determine whether these findings are also found in clinically unaffected siblings of schizophrenics and estimate heritability by calculating relative risk. We investigated two independent data sets: (1) from the NIMH St. Elisabeth's campus (59 schizophrenics, 76 unaffected siblings and 32 unrelated normal controls) and (2) from the NIH-campus (Bethesda) (59 schizophrenics, 90 unaffected siblings and 26 unrelated normal controls). We computed power spectra and coherence on the first data set and then tried to replicate the results on the second data set. Power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (lambda(S)) ranged between 3.7 and 9.8, depending on phenotype ...Continue Reading

References

Sep 1, 1976·Electroencephalography and Clinical Neurophysiology·D H IngvarA Ardö
Nov 1, 1976·The Journal of Nervous and Mental Disease·J J Bartko, W T Carpenter
Oct 1, 1992·Schizophrenia Research·E L Merrin, T C Floyd
Jan 1, 1992·Annual Review of Psychology·D C Fowles
Nov 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·S L Morrison-StewartH Merskey
Jan 1, 1991·The Journal of Neuropsychiatry and Clinical Neurosciences·R E HoffmanS M Guich
Jan 1, 1991·European Archives of Psychiatry and Clinical Neuroscience·S MichelogiannisP Trikas
Mar 1, 1991·Biological Psychiatry·D R Weinberger
Aug 1, 1987·Electroencephalography and Clinical Neurophysiology·T GasserR Verleger
Jan 1, 1989·Biological Psychiatry·E L MerrinG Fein
Jul 1, 1988·Comprehensive Psychiatry·H Helmchen
Jan 1, 1988·Schizophrenia Bulletin·C N KarsonD R Weinberger
Jun 1, 1987·Archives of General Psychiatry·C N KarsonD R Weinberger
Dec 1, 1984·Biological Psychology·P Flor-Henry, Z J Koles
Apr 1, 1995·Fortschritte der Neurologie-Psychiatrie·J TauscherS Kasper
Sep 1, 1994·Psychophysiology·D A SmithS B Schwarzkopf
May 1, 1996·Schizophrenia Research·E L Merrin, T C Floyd
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Mar 1, 1997·Electroencephalography and Clinical Neurophysiology·M Corsi-CabreraM A Guevara
May 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·S E ChuaP K McGuire
Oct 31, 1997·Clinical EEG (electroencephalography)·V J Knott, A Harr
Feb 7, 1998·Current Opinion in Neurobiology·M F Egan, D R Weinberger
Sep 10, 1998·Neuropsychobiology·V J KnottC Mahoney
Jun 11, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P L NunezR S Wijesinghe
Jul 28, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G WintererR Coppola
May 10, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G WintererR Coppola
Sep 29, 2000·European Archives of Psychiatry and Clinical Neuroscience·G WintererW M Herrmann
Apr 11, 2001·Schizophrenia Research·Y Wuebben, G Winterer

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Citations

Dec 4, 2003·Biological Psychiatry·Georg WintererDaniel R Weinberger
Sep 26, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Margarita Alfimova, Lubov Uvarova
Jul 4, 2003·Psychiatry and Clinical Neurosciences·Roland KalbJohannes Kornhuber
Dec 31, 2011·The Journal of Biological Chemistry·William F SchwindingerJanet D Robishaw
May 9, 2007·Schizophrenia Bulletin·Andreas Konrad, Georg Winterer
May 28, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Katherine R HenshallDavid L Copolov
Aug 23, 2012·Schizophrenia Research·Matthew J HoptmanDaniel C Javitt
Dec 28, 2007·Schizophrenia Research·Nash N BoutrosWilliam Iacono
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kylie J Barnett, Ian J Kirk
Aug 30, 2005·Psychiatry Research·Anusha SritharanDavid Copolov
Feb 4, 2014·Schizophrenia Research·Siri RanlundElvira Bramon
Jun 17, 2003·Acta Psychiatrica Scandinavica·G WintererD Goldman
Aug 19, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Hui-Jie LiXi-Nian Zuo
Jul 22, 2014·Glia·Robert F FernPeter K Stys
Aug 30, 2014·Schizophrenia Bulletin·Christina AndreouChristoph Mulert
Jun 19, 2009·Clinical EEG and Neuroscience·Silvana GalderisiNash Boutros
Mar 28, 2003·Molecular Psychiatry·G M InnocentiJ Parnas
Jan 30, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Georg WintererThomas Sander
Apr 3, 2008·Schizophrenia Bulletin·Noah C VenablesScott R Sponheim
Nov 30, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Shuixia GuoLena Palaniyappan
Sep 11, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniMark Hallett
Jul 1, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Derek K HuElizabeth A Martin
Aug 18, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stavros I Dimitriadis
Apr 16, 2018·Neuroscience and Biobehavioral Reviews·Thomas J ReillyPhilip McGuire
Oct 21, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Claudio BabiloniClaudio Del Percio

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