An association study of ADSS gene polymorphisms with schizophrenia.

Behavioral and Brain Functions : BBF
Fuquan ZhangPozi Liu

Abstract

Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not. We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform. The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups. Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations.

References

Oct 18, 1996·The Journal of Biological Chemistry·B E CruteN A Speck
Jan 6, 1999·Controlled Clinical Trials·W D Dupont, W D Plummer
May 3, 2002·Molecular Psychiatry·J A Badner, E S Gershon
Jun 13, 2003·American Journal of Human Genetics·Cathryn M LewisTomas Helgason
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Jan 27, 2004·Schizophrenia Research·Marquis P VawterWilliam Byerley
Jul 21, 2004·Molecular Psychiatry·P J Harrison, D R Weinberger
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jan 13, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ming T TsuangC C Liew
May 27, 2005·PLoS Medicine·Sukanta SahaJohn McGrath
Jun 3, 2005·The Journal of Clinical Investigation·George KirovMichael J Owen
Jan 31, 2006·Biological Psychiatry·Paul J Harrison, Amanda J Law
Mar 15, 2006·Trends in Pharmacological Sciences·Joseph A Gogos, David J Gerber
Apr 4, 2006·Biological Psychiatry·Sevilla D Detera-Wadleigh, Francis J McMahon
Apr 14, 2006·Current Opinion in Psychiatry·Nadine NortonMichael J Owen
May 25, 2006·European Journal of Human Genetics : EJHG·Brien Riley, Kenneth S Kendler
Jul 18, 2006·Biological Psychiatry·Richard E Straub, Daniel R Weinberger
Mar 10, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xinyun LiKui Li
Apr 10, 2007·Psychiatric Genetics·Bartosz KempistyPaweł Piotr Jagodzinski
May 8, 2007·Biological Psychiatry·Paul J Harrison
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hao-Yang TanJoseph H Callicott
Jul 31, 2007·Journal of Medical Genetics·P VahteristoL A Aaltonen
Aug 28, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hon-Cheong SoPak C Sham

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

PLINK
Haploview
UNPHASED
[UNK] typer
COCAPHASE
SHEsis
QTPHASE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.