An astroblastoma case associated with loss of heterozygosity on chromosome 9p.

Journal of Neuro-oncology
Nobuhiro HataTomio Sasaki

Abstract

The tumorigenesis of astroblastomas has not yet been elucidated on the basis of histopathological studies, and genetic studies may be useful for obtaining additional information regarding the tumorigenesis of these tumors. Here, we report an astroblastoma case in which a genetic analysis was performed. A 16-year-old female with a progressive headache was found to have a demarcated cystic tumor with a mural nodule in the right parietal lobe. Total removal of the tumor was achieved and a histological examination verified that the tumor was an astroblastoma. A genetic analysis using microsatellite markers revealed loss of heterozygosity (LOH) on chromosome 9p. The postoperative course was uneventful and, to date, she has been followed up for 2 years with no signs of recurrence. This is the first reported case of an astroblastoma in which LOH was detected on 9p. Based on this result, the tumorigenesis of astroblastomas is discussed.

References

Jan 2, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·S ShuangshotiA Mutirangura
Jan 5, 2002·Journal of Neuro-oncology·S BortolottoD Schiffer
May 17, 2002·The Journal of Pathology·Judith W M JeukenPieter Wesseling
Jul 20, 2002·Cancer Genetics and Cytogenetics·Ronald KoschnyMargit A Zuber

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Citations

Apr 22, 2018·Journal of Medical Case Reports·Nawal HammasLaila Chbani
May 10, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Supriya MallickGoura K Rath
Oct 30, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ryusuke HataeKoji Iihara
Nov 25, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ryo KurokawaToshio Moritani

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