An athymic rat model of cutaneous radiation injury designed to study human tissue-based wound therapy.

Radiation Oncology
Lucas H RifkinTimothy D Solberg

Abstract

To describe a pilot study for a novel preclinical model used to test human tissue-based therapies in the setting of cutaneous radiation injury. A protocol was designed to irradiate the skin of athymic rats while sparing the body and internal organs by utilizing a non-occlusive skin clamp along with an x-ray image guided stereotactic irradiator. Each rat was irradiated both on the right and the left flank with a circular field at a 20 cm source-to-surface distance (SSD). Single fractions of 30.4 Gy, 41.5 Gy, 52.6 Gy, 65.5 Gy, and 76.5 Gy were applied in a dose-finding trial. Eight additional wounds were created using the 41.5 Gy dose level. Each wound was photographed and the percentage of the irradiated area ulcerated at given time points was analyzed using ImageJ software. No systemic or lethal sequelae occurred in any animals, and all irradiated skin areas in the multi-dose trial underwent ulceration. Greater than 60% of skin within each irradiated zone underwent ulceration within ten days, with peak ulceration ranging from 62.1% to 79.8%. Peak ulceration showed a weak correlation with radiation dose (r = 0.664). Mean ulceration rate over the study period is more closely correlated to dose (r = 0.753). With the highest dose e...Continue Reading

Associated Clinical Trials

Jul 8, 2020·Moustafa Ali Ghazi Al-Shammari

References

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Citations

Aug 16, 2014·Zeitschrift für medizinische Physik·Falk TillnerWolfgang Enghardt
Aug 5, 2015·Radiation Oncology·Sebastian OeckVerena Jendrossek
Mar 27, 2018·Plastic and Reconstructive Surgery·Kasandra R DassoulasKant Y Lin
Sep 9, 2017·PloS One·Kazutoshi FujitaMasao Kakibuchi
Jun 27, 2015·The Journal of Craniofacial Surgery·Mustafa HasdemirErdal Karaöz
Feb 2, 2016·Tissue Engineering and Regenerative Medicine·Im Geon JinSoon Jung Hwang
Dec 30, 2014·Plastic and Reconstructive Surgery·Alexander F MericliKant Y Lin
Apr 11, 2019·International Ophthalmology·Sepehr FeiziAmir A Azari
Dec 16, 2016·Physics in Medicine and Biology·E FordN Mayr
Mar 25, 2017·Journal of Radiation Research·Elizabeth A McCartRegina M Day

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Methods Mentioned

BETA
X-Ray
irradiate

Software Mentioned

ImageJ

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