An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Victor D MartinezWan L Lam

Abstract

The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.

References

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Apr 28, 2006·Nature Genetics·Michael ReichJill P Mesirov
Jan 5, 2007·The New England Journal of Medicine·Hsuan-Yu ChenPan-Chyr Yang
Nov 3, 2007·Science·Alexei A AravinJulius Brennecke
Jun 23, 2009·Genome Research·Martin KrzywinskiMarco A Marra
Dec 22, 2009·Current Biology : CB·Nicolas RobineEric C Lai
May 28, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jia ChengQing-Ning Li
Jan 25, 2014·Expert Reviews in Molecular Medicine·Hua-Hsi WuKuo-Wang Tsai
Jul 26, 2014·Cancer Gene Therapy·Z ZhangA Zang
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Aug 20, 2014·Nature Reviews. Gastroenterology & Hepatology·Mairi H McLean, Emad M El-Omar

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Citations

Jan 16, 2016·Molecular Cancer·Kevin W NgVictor D Martinez
Oct 8, 2016·Transcription·Didier Auboeuf
Oct 30, 2018·Nucleic Acids Research·Jiajia WangShunmin He
Jan 11, 2018·Scientific Reports·Victor D MartinezKevin L Bennewith
Oct 23, 2016·Oncotarget·Preethi KrishnanSambasivarao Damaraju
Nov 16, 2019·Aging·Ye ChengWeihong Shi
Sep 8, 2020·Cancer Metastasis Reviews·Rachel E SextonAsfar S Azmi
Mar 25, 2020·International Journal of Molecular Sciences·Gleyce Fonseca CabralÂndrea Ribeiro-Dos-Santos
Nov 20, 2019·International Journal of Molecular Sciences·Michelle E PewarchukWan L Lam
Oct 2, 2019·International Journal of Molecular Sciences·Rachel SextonAsfar S Azmi
Jan 22, 2020·Cancer Metastasis Reviews·Binghong GuoXiao Zhu
Aug 11, 2019·Molecular Cancer·Yongmei LiuWenhua Xu
Oct 22, 2020·International Journal of Molecular Sciences·Tatiana Vinasco-SandovalSidney Santos
Nov 11, 2020·Journal of Cellular and Molecular Medicine·Lichen GeJunjun Wang
Feb 13, 2021·Biochemical Pharmacology·B BaptistaF Sousa
May 5, 2021·Journal of Cellular and Molecular Medicine·Kai WangLu-Yu Zhou
May 8, 2021·Cancer Medicine·Emmi KärkkäinenJaana M Hartikainen
Jul 23, 2021·Genes & Diseases·Jing-Fen SuFu-You Zhou
Nov 2, 2021·Bioengineered·Pooneh MokarramHassan Ashktorab
Sep 3, 2020·Seminars in Cancer Biology·Yuan LinDongxin Lin

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