PMID: 9538691Apr 16, 1998Paper

An atlas of serpin conformations

Trends in Biochemical Sciences
J C WhisstockA M Lesk

Abstract

The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed-->relaxed (S-->R) transition. This article is a guide to the known serpin conformations and their biological significance.

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