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An atomic model of brome mosaic virus using direct electron detection and real-space optimization

Nature Communications

Sep 5, 2014

Zhao WangWah Chiu

Abstract

Advances in electron cryo-microscopy have enabled structure determination of macromolecules at near-atomic resolution. However, structure determination, even using de novo methods, remains susceptible to model bias and overfitting. Here we describe a complete workflow for data acquisiti...read more

Mentioned in this Paper

Crystallography, X-Ray
Microscopy
RNA Viruses
Brome mosaic virus
Macromolecule
1
83
Paper Details
References
  • References44
  • Citations31
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  • References44
  • Citations31
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An atomic model of brome mosaic virus using direct electron detection and real-space optimization

Nature Communications

Sep 5, 2014

Zhao WangWah Chiu

PMID: 25185801

DOI: 10.1038/ncomms5808

Abstract

Advances in electron cryo-microscopy have enabled structure determination of macromolecules at near-atomic resolution. However, structure determination, even using de novo methods, remains susceptible to model bias and overfitting. Here we describe a complete workflow for data acquisiti...read more

Mentioned in this Paper

Crystallography, X-Ray
Microscopy
RNA Viruses
Brome mosaic virus
Macromolecule
1
83

Related Papers

Paper Details
References
  • References44
  • Citations31
12345
  • References44
  • Citations31
1234
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