Apr 14, 2010

An ATPase promotes autophosphorylation of the pattern recognition receptor XA21 and inhibits XA21-mediated immunity

Proceedings of the National Academy of Sciences of the United States of America
Xuewei ChenPamela C Ronald

Abstract

Cell-surface pattern recognition receptors (PRRs) are key components of the innate immune response in animals and plants. These receptors typically carry or associate with non-RD kinases to control early events of innate immunity signaling. Despite their importance, the mode of regulation of PRRs is largely unknown. Here we show that the rice PRR, XA21, interacts with XA21 binding protein 24 (XB24), a previously undescribed ATPase. XB24 promotes autophosphorylation of XA21 through its ATPase activity. Rice lines silenced for Xb24 display enhanced XA21-mediated immunity, whereas rice lines overexpressing XB24 are compromised for immunity. XB24 ATPase enzyme activity is required for XB24 function. XA21 is degraded in the presence of the pathogen-associated molecular pattern Ax21 when XB24 is overexpressed. These results demonstrate a function for this large class of broadly conserved ATPases in PRR-mediated immunity.

Mentioned in this Paper

Immune Response
Rice (Dietary)
Chimeric Proteins, Recombinant
Porcine Reproductive and Respiratory Syndrome
Adenosine Triphosphatases
Pathogenic Organism
Cosuppression
Hormone Receptors, Cell Surface
Reverse Transcriptase Polymerase Chain Reaction
Autophosphorylation

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