PMID: 9524081Apr 2, 1998Paper

An attempt to treat pediatric intracranial alphaFP and betaHCG secreting germ cell tumors with chemotherapy alone. SFOP experience with 18 cases. Société Française d'Oncologie Pédiatrique

Journal of Neuro-oncology
M C BaranzelliC Kalifa

Abstract

Intracranial alphaFP and betaHCG secreting germ cell tumors have a very poor prognosis with local treatment alone. Because of efficacy of chemotherapy in extracranial forms, we tried in the SFOP (Société Française d'Oncologie Pédiatrique) to treat them with chemotherapeutic treatment exclusively. Eighteen patients (10 alphaFP, 2 betaHCG, 6 alphaFP and betaHCG secretion) were enrolled from January 1988 to December 1992. After biological diagnosis patients were to receive 6 cycles of chemotherapy (vinblastine bleomycin - carboplatin or etoposide - carboplatin/ifosfamide - etoposide). After completion of chemotherapy, surgery was to be performed in case of residual tumor. Focal radiation was only to be delivered in case of viable residual tumor. All patients had biological remission and tumor reduction. Fifteen patients were treated according to the protocol by chemotherapy alone (13) or chemotherapy and radiation of residue (2). Twelve of the 13 non irradiated patients relapsed, 8 in local and/or regional area, 3 in cerebrospinal area and 1 in undeterminated area with mild elevation of markers except in one case. Six patients are alive in second complete remission after chemotherapy and/or surgery and then a consolidation treatme...Continue Reading

Citations

Feb 17, 2000·Current Opinion in Neurology·B S Hooda, J L Finlay
Aug 5, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mohammad H Abu ArjaMohamed S AbdelBaki
Apr 23, 2004·Current Neurology and Neuroscience Reports·Casilda Balmaceda, Jonathan Finlay
Sep 19, 2014·Current Opinion in Oncology·Christelle DufourJacques Grill
Nov 17, 1998·Journal of Neurosurgery·Y SawamuraH Shirato
Feb 26, 2013·Medical Oncology·Jigisha P ThakkarJ Lee Villano
May 31, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Sajeel ChowdharyMarc C Chamberlain
Feb 16, 2019·Pediatric Blood & Cancer·Mohammad H Abu ArjaMohamed S AbdelBaki
Aug 11, 2000·Paediatric Drugs·E Bouffet
Jun 26, 2009·Journal of Neuro-oncology·Michael L DiLunaJoseph M Piepmeier
Mar 10, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·I-Chun LaiYi-Wei Chen
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May 7, 2015·Japanese Journal of Radiology·Masahiro KenjoYasushi Nagata
Apr 5, 2011·Journal of Neurosurgery. Pediatrics·Hideo NakamuraJun-ichi Kuratsu
May 4, 2017·International Journal of Cancer. Journal International Du Cancer·Matthew J MurrayJames C Nicholson
Jul 28, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laetitia CallecCecile Faure-Conter
Sep 25, 2021·Pediatric Blood & Cancer·Mohammad H Abu-ArjaMohamed S Abdelbaki

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