An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis

Cell
Ben RoedigerWolfgang Weninger

Abstract

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.

Citations

Apr 24, 2019·Viruses·Mario MietzschMavis Agbandje-McKenna
Jun 27, 2019·The ISME Journal·Michelle WilleEdward C Holmes
Sep 5, 2019·Viruses·Matheus A DuarteFabrício S Campos
Jun 26, 2020·Journal of Virology·Wei-Shan ChangEdward C Holmes
Jun 24, 2020·Lab Animal·Alla Katsnelson
May 1, 2019·Viruses·Elizabeth FahsbenderEric Delwart
Sep 29, 2018·Nature Reviews. Nephrology·Monica Wang
Aug 8, 2020·Open Forum Infectious Diseases·Kei NishiyamaShouichi Ohga
Oct 30, 2020·Journal of Virology·Yanpeng LiEric Delwart
Feb 10, 2021·Transboundary and Emerging Diseases·Federica Di ProfioBarbara Di Martino
Dec 18, 2020·PloS One·Charles E AlexPatricia A Pesavento
Apr 21, 2021·Epigenomics·Huanhou SuLijing Wang
May 16, 2020·Current Biology : CB·Keir M BallaNels C Elde
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Stephanie Buchheister, André Bleich

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