PMID: 7547521Jan 1, 1995Paper

An audit of craniospinal irradiation for medulloblastoma in Newcastle 1970-1992

Clinical Oncology : a Journal of the Royal College of Radiologists
D Tinkler, H H Lucraft

Abstract

The case notes were reviewed of 55 patients treated with craniospinal irradiation for cerebellar medulloblastoma during the period 1970-1992. Twenty patients treated by various techniques before 1978 had a survival at both 5 and 10 years of 33%. Thirty-five patients treated from 1978 onwards were irradiated using a standard technique, which is described; their actuarial disease free survival was 59% at 5 years and 47% at 10 years. Our results are similar to those reported from other centres. The recent literature is reviewed. Irradiation of the whole craniospinal axis (CSA) is necessary for disease control, but the optimum dose of radiation is still disputed. It is likely to be in excess of 25 Gy but less than 35 Gy to the whole CSA, and 50 Gy or greater to the posterior fossa. The role of adjuvant chemotherapy is still not proven. The clinical significance of the dose inhomogeneity across the junction between the cranial and spinal fields, and the effect of feathering, are uncertain.

References

Jun 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C CarrieT Pignon
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E BouffetC Lapras
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·F E HalbergC B Wilson
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M TaitP Morris-Jones
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·D JenkinH Hoffman
Oct 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Tatcher, A S Glicksman
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M Deutsch
Nov 1, 1987·International Journal of Radiation Oncology, Biology, Physics·W N BrandR P Tokars
Apr 1, 1985·International Journal of Radiation Oncology, Biology, Physics·M H MaorJ van Eys
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H J Bloom
Feb 15, 1980·Cancer·T G LandbergS E Cronqvist
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·C L Silverman, J R Simpson
Jul 1, 1981·Journal of Neurosurgery·M P BerryW J Simpson
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·E J HolupkaG K Svensson

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Citations

Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers

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