An augmented aging process in brain white matter in HIV

Human Brain Mapping
Taylor KuhnApril D Thames

Abstract

HIV infection and aging are both associated with neurodegeneration. However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear. HIV+ (n = 70) and HIV-negative (HIV-, n = 34) participants underwent diffusion tensor imaging (DTI) and metrics of microstructural properties were extracted from regions of interest (ROIs). A support vector regression model was trained on two independent datasets of healthy adults across the adult life-span (n = 765, Cam-CAN = 588; UiO = 177) to predict participant age from DTI metrics, and applied to the HIV dataset. Predicted brain age gap (BAG) was computed as the difference between predicted age and chronological age, and statistically compared between HIV groups. Regressions assessed the relationship between BAG and HIV severity/medical comorbidities. Finally, correlation analyses tested for associations between BAG and cognitive performance. BAG was significantly higher in the HIV+ group than the HIV- group F (1, 103) = 12.408, p = .001). HIV RNA viral load was significantly associated with BAG, particularly in older HIV+ individuals (R2  = 0.29, F(7, 70) = 2.66...Continue Reading

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Citations

Jul 5, 2019·Human Brain Mapping·Taylor KuhnApril D Thames
Jan 5, 2020·Neurotoxicity Research·Ashley HenneghanShelli R Kesler
Oct 13, 2018·AIDS and Behavior·David P SheppardPaul E Gilbert
Feb 24, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalen J PetersenBeau M Ances
Aug 14, 2021·BMC Neurology·Jo WrigglesworthJoanne Ryan
Oct 10, 2021·Human Brain Mapping·Dani BeckLars T Westlye

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