An auto-perfusing umbilical cord blood collection instrument

ISA Transactions
K K TanL G Tan

Abstract

In this paper, the development of an automated umbilical cord blood (UCB) collection instrument, comprising of mechanical, electronics and control components, is provided in detail. UCB from the placenta provides a rich source of highly proliferative cells for many clinical uses as it contains rich Hematopoietic Stem Cells (HSCs) which yield many benefits over traditional sources such as the bone marrow and periphery blood. Current collection of UCB uses a syringe to extract blood from placenta, which is highly limited in volume and cell numbers. This paper will present the development of an automated UCB collection instrument to yield improved performance which comprised four subsystems. First, a placenta handling system is designed to produce air pressure which can realize the emulation of the uterus compression on the placenta. Second, an auto-medium injector system is presented to enable perfusion automatically. Third, a time window widening system is developed which generates vibrations during the perfusion phase and helps the exposed end of the cord cool down to a low temperature. Finally, a control platform is used to integrate all systems working together, hosting the control algorithms which operate the instrument auto...Continue Reading

References

Jan 1, 2009·F1000 Medicine Reports·Yi-Bin Chen, Karen K Ballen
Jan 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael BooMartin Maiers
May 20, 2011·IEEE Transactions on Bio-medical Engineering·Alexandros Karargyris, Nikolaos Bourbakis
May 31, 2011·IEEE Transactions on Bio-medical Engineering·Zhanfeng JiMasatoshi Nakamura
Jun 30, 2011·IEEE Transactions on Bio-medical Engineering·Illapha Cuba Gyllensten, Alberto G Bonomi
Sep 13, 2011·IEEE Transactions on Bio-medical Engineering·Christoph S GarbeOliver Friedrich
Oct 20, 2011·IEEE Transactions on Bio-medical Engineering·Axel KriegerLouis L Whitcomb
Jan 1, 2010·Stem Cells and Cloning : Advances and Applications·Satish ShanbhagRobert Vb Emmons

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