An Automated and Minimally Invasive Tool for Generating Autologous Viable Epidermal Micrografts

Advances in Skin & Wound Care
Sandra N OsborneJohn R Harper

Abstract

A new epidermal harvesting tool (CelluTome; Kinetic Concepts, Inc, San Antonio, Texas) created epidermal micrografts with minimal donor site damage, increased expansion ratios, and did not require the use of an operating room. The tool, which applies both heat and suction concurrently to normal skin, was used to produce epidermal micrografts that were assessed for uniform viability, donor-site healing, and discomfort during and after the epidermal harvesting procedure. This study was a prospective, noncomparative institutional review board-approved healthy human study to assess epidermal graft viability, donor-site morbidity, and patient experience. These studies were conducted at the multispecialty research facility, Clinical Trials of Texas, Inc, San Antonio. The participants were 15 healthy human volunteers. The average viability of epidermal micrografts was 99.5%. Skin assessment determined that 76% to 100% of the area of all donor sites was the same in appearance as the surrounding skin within 14 days after epidermal harvest. A mean pain of 1.3 (on a scale of 1 to 5) was reported throughout the harvesting process. Use of this automated, minimally invasive harvesting system provided a simple, low-cost method of producing un...Continue Reading

References

Dec 28, 1994·Journal of Immunological Methods·N G PapadopoulosM Papamichail
Jan 16, 1998·Burns : Journal of the International Society for Burn Injuries·S DasguptaA Sarkar
Jan 6, 1999·Archives of Dermatology·M D NjooP M Bossuyt
Sep 16, 1999·International Journal of Dermatology·A F AlexisM J Stiller
Dec 14, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S GuptaP K Saraswat
Oct 20, 2000·Plastic and Reconstructive Surgery·J S Burm
Aug 9, 2007·Rheumatology International·Yoshiro Ichiki, Yasuo Kitajima
Feb 5, 2008·Genes & Development·John L RinnHoward Y Chang
Jan 27, 2010·Indian Journal of Dermatology·Niti KhungerV Ramesh
Apr 13, 2010·Burns : Journal of the International Society for Burn Injuries·Yener DemirtasAhmet Demir
Jul 29, 2010·Journal of Diabetes Science and Technology·Atanu BiswasHoracio Rilo
Feb 9, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ruka SimizuNobuaki Imanishi

❮ Previous
Next ❯

Citations

Aug 23, 2016·International Wound Journal·Agata JanowskaMarco Romanelli
Aug 23, 2016·International Wound Journal·Ingrid HerskovitzRobert Kirsner
Oct 28, 2017·International Wound Journal·Peter Am EvertsJaap Buth
Oct 18, 2018·Journal of Wound Care·Majana Tomic-CanicHans Smola
Mar 31, 2021·Burns : Journal of the International Society for Burn Injuries·Malachy AsukuMatthias B Donelan
Jul 10, 2018·Advanced Drug Delivery Reviews·Patricia RousselleGuila Dayan

❮ Previous
Next ❯

Software Mentioned

Pro Plus
IntegReview
Image
Leica Application Suite

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.