An automated pressure-swing absorption system to administer low oxygen therapy for persons with spinal cord injury.

Experimental Neurology
Andrew Quesada TanRandy D Trumbower

Abstract

Mild episodes of breathing low oxygen (O2) (i.e., acute intermittent hypoxia, AIH) elicits rapid mechanisms of neural plasticity that enhance respiratory and non-respiratory motor function after spinal cord injury (SCI). Despite promising outcomes in humans and rodents with SCI, the translational potential of AIH as a clinical therapy remains dependent on a safer and more reliable air delivery system. The purpose of this study is to investigate the performance of a novel AIH delivery system to overcome inconsistencies in human AIH protocols using a hand-operated (manual) delivery system. Specifically, we characterized system performance of AIH delivery in terms of flow rate, O2 concentration, dose timing, and air temperature. Our data show that a novel 'automated' delivery system: i) produces reliable AIH with a goodness-of-fit at 98.1% of 'ideal'; ii) eliminates dose timing errors via programmable solenoid switches; iii) reduces fluctuations in O2 to less than 0.01%; and iv) delivers 62.7% more air flow than the 'manual' delivery method. Automated physiological recordings, threshold detection, and visual feedback of the participant's blood O2 saturation, heart rate, and blood pressure ensures real-time user safety. In summary,...Continue Reading

Associated Clinical Trials

Dec 16, 2015·Randy Trumbower, PT, PhD

References

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May 20, 2016·The Journal of Spinal Cord Medicine
May 6, 2020·American Journal of Respiratory and Critical Care Medicine·Isabelle VivodtzevRandy D Trumbower

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