PMID: 9438075Jan 23, 1998Paper

An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism

Brain Research. Brain Research Protocols
G RozasJ L Labandeira-García

Abstract

A variety of tests have been proposed for evaluation of motor deficits in rat models of hemiparkinsonism. The most widely used test, the "rotational behaviour" test, is based upon motor asymmetry induced by drug administration, leading to problems of sensitization, conditioning and priming. In addition, lesion-induced rotational behaviour is sometimes overcompensated by treatments (grafts) while other deficits are unaffected. However, rotational behaviour is reproducible and easy to quantify. On the contrary, most drug-free tests have proved of limited applicability because of subjective scaling, excessive interaction between the experimenter and animals, motivational effects, excessively complex tasks, etc., making it difficult to compare results from different laboratories. In this paper, we present a rotarod based method for automated drug-free evaluation of overall motor deficits in the rat model of hemiparkinsonism, and for identifying treatment-induced changes. Animals are pre-trained on the rotarod and then tested at a series of increasing rod speeds; from this set of values a unique score for each animal is computed (the overall rotarod performance, ORP) summarizing its performance at different speeds. This value is eas...Continue Reading

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Citations

Oct 6, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·George I JalloMargaret B Penno
Mar 25, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica A L Hutter-SaundersR Lee Mosley
Jun 1, 2005·Behavioural Brain Research·Ruxandra IancuGesine Paul
Mar 31, 2004·Journal of the Neurological Sciences·Shunmei ChibaNoboru Suzuki
Apr 15, 2004·Neurobiology of Learning and Memory·Manuel M BuitragoAndreas R Luft
Oct 9, 1998·Journal of Neuroscience Methods·G RozasJ L Labandeira-García
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matteo MartiMichele Morari
Jan 5, 2007·Spine·Marc-Antoine A RousseauJeffrey C Lotz
Mar 22, 2014·Pflügers Archiv : European journal of physiology·Dae Yun SeoJin Han
Feb 26, 2014·The Journal of Physiology·Riccardo ViaroGianfranco Franchi
Jul 25, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanna PaoloneMichele Morari
Mar 29, 2013·Neurochemistry International·Angélica CoyoyJulio Morán
Jul 14, 2012·Neurotoxicology and Teratology·Mohammad Hossein EsmaeiliHashem Haghdoost-Yazdi
May 29, 2007·Biochemical and Biophysical Research Communications·Suk Ho BhangByung-Soo Kim
Feb 19, 2009·Journal of Neuroscience Research·Randy L HunterGuoying Bing

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