PMID: 6088024Oct 1, 1984Paper

An autoradiographic study on the labeling index of biopsy specimens from gastric cancers

Cancer
K SasakiS Okuda

Abstract

With the aim of examining proliferative activity of gastric cancers of various histologic types, H3-thymidine labeling indices of biopsy specimens from 48 patients were examined using an in vitro labeling technique. The results indicated that the indices were greatly variable (1.4-40.8%) from case to case and from area to area, and could not be well correlated with either gross findings, histologic types, or the degree of tumor invasion. However, the distribution of the labeled cells within the tumor was somewhat characteristic to each histologic type. In adenocarcinomas, DNA-synthesizing cells were scattered at random over the entire tumor tissue. In signet-ring cell carcinomas, small tumor cells with dark-staining cytoplasm were preferentially labeled. In contrast, typical signet-ring cells had practically zero labeling index, suggesting that they are out-of-cycle cells and are functionally differentiated.

Citations

Apr 1, 1994·Journal of Surgical Oncology·N TanigawaT Tanaka
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·N Zafar, J C Macartney
Mar 12, 1991·International Journal of Cancer. Journal International Du Cancer·R PorschenF Borchard
Jun 1, 1989·Pathology, Research and Practice·K MatsumuraM Takahashi
Jun 1, 1989·Pathology, Research and Practice·K SasakiK Kawachnino
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K SaitohK Nakamura
Oct 1, 1986·The Journal of Pathology·N W Wilson, J C Macartney
Apr 1, 1986·The Journal of Pathology·J C MacartneyG Powell
Jan 1, 1993·Cancer·D AmadoriA Saragoni
May 15, 1992·Cancer·A YoshidaK Ito
Oct 1, 1989·The Journal of Urology·H TsujihashiT Kurita

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