Abstract
Glioma is highly lethal because of its high malignancy. Ubiquitination, a type of ubiquitin-dependent protein modification, has been reported to play an oncogenic or tumor-suppressive role in glioma development, depending on the targets. Ring finger protein 139 (RNF139) is a membrane-bound E3 ubiquitin ligase serving as a tumor suppressor by ubiquitylation-dependently suppressing cell growth. Herein, we firstly confirmed the abnormal downregulation of RNF139 in glioma tissues and cell lines. In glioma cells, ectopic RNF139 overexpression could inhibit, whereas RNF139 knockdown could aggravate the aggressive behaviors of glioma cells, including hyperproliferation, migration, and invasion. Moreover, in two glioma cell lines, RNF139 overexpression inhibited, whereas RNF139 knockdown enhanced the phosphorylation of phosphatidylinositol 3-kinase (PI3K) and AKT serine/threonine kinase 1 (AKT). In a word, we demonstrate the aberration in RNF139 expression in glioma tissue samples and cell lines. RNF139 serves as a tumor-suppressor in glioma by inhibiting glioma cell proliferation, migration, and invasion and promoting glioma cell apoptosis through regulating PI3K/AKT signaling.
References
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A CiechanoverG M Brodeur
Oct 17, 1986·Science·S RogersM Rechsteiner
May 1, 1984·Cell·A CiechanoverA Varshavsky
Sep 8, 1995·Science·A KibelW G Kaelin
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R M GemmillH A Drabkin
May 25, 1999·Cell·D M KoeppS J Elledge
Jun 8, 1999·Annual Review of Immunology·K L Rock, A L Goldberg
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Mar 14, 2001·Journal of Neuro-oncology·M KirschP M Black
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Mar 4, 2003·Nature Reviews. Molecular Cell Biology·Masafumi Muratani, William P Tansey
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnab ChakravartiJay S Loeffler
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Aaron Ciechanover
Oct 4, 2006·Oncogene·A BrauweilerR M Gemmill
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Aug 1, 2009·Molecular Cancer·Stefania GimelliGiorgio Gimelli
Jun 13, 2012·Oncogene·P-H LinL-Y Chau
Apr 24, 2013·Archives of Medical Research·Yang ChenYing Zhang
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
May 21, 2014·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Feb 27, 2015·Cancer Research·Markus E DiefenbacherAxel Behrens
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
Jun 13, 2015·Scientific Reports·Si-Jian PanQing-Fang Sun
Nov 19, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiang TongXian-Ming Chen
Mar 12, 2016·Oncotarget·Xiaoman LiLiang Wang
Apr 5, 2017·Annual Review of Biochemistry·Ning Zheng, Nitzan Shabek
Jun 9, 2017·Molecular Cancer·Hua-Fu ZhaoWei-Ping Li
Jul 1, 2017·BMC Cancer·Lina WangChun Shi
Jan 19, 2018·Oncogene·Maolei ZhangNu Zhang
Feb 21, 2018·Molecular Cancer·Zixuan PengMinghua Wu
Sep 7, 2019·Nature Communications·Youzhou SangHaizhong Feng