An EAACI task force report: recognising the potential of the primary care physician in the diagnosis and management of drug hypersensitivity

Clinical and Translational Allergy
I DoñaM J Torres

Abstract

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs. Primary care physicians are often the first point of contact for the sufferer of a reaction, as such they have a key role in deciding whether to discard the diagnosis or send the patient for further investigation. In this review, we highlight the importance of diagnosing DHRs, analysing in detail the role of primary care physicians. We describe the common patterns of DHRs and signs of its progression, as well as the indications and contraindications for referring the patient to an allergist. The diagnostic process is described and the possible tests are discussed, which often depend on the drug involved and the t...Continue Reading

References

Mar 26, 2003·Clinical and Experimental Dermatology·C E H Grattan
Aug 13, 2003·Allergy·W AbererUNKNOWN EAACI interest group on drug hypersensitivity
Sep 27, 2003·Allergy·M J TorresUNKNOWN EAACI Interest Group on Drug Hypersensitivity
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Gisèle KannyD Anne Moneret-Vautrin
Jan 14, 2005·Allergy·K BrockowUNKNOWN EAACI interest group on drug hypersensitivity
Jul 13, 2005·Archives of Internal Medicine·Said BenahmedPascal Demoly
Jun 8, 2006·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Yasser ShehataAziz Sheikh
Oct 5, 2006·Current Pharmaceutical Design·C AntúnezM Blanca
Oct 10, 2008·The Journal of Allergy and Clinical Immunology·Malgorzata SetkowiczAndrzej Szczeklik
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E GómezC Mayorga
Jan 23, 2010·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Michael HazeldineAziz Sheikh
Mar 9, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W EwanUNKNOWN BSACI
Jul 9, 2010·The Medical Clinics of North America·Kathrin Scherer, Andreas J Bircher
Jul 9, 2010·The Medical Clinics of North America·Ticha Limsuwan, Pascal Demoly
Jul 9, 2010·The Medical Clinics of North America·Andreas J Bircher, Kathrin Scherer
Aug 19, 2010·Allergy·J R CernadasUNKNOWN European Network of Drug Allergy and the EAACI interest group on drug hypersensitivity
Oct 5, 2010·The Journal of Allergy and Clinical Immunology·Antonino RomanoPhilippe Jean Bousquet
Nov 3, 2010·The Journal of Allergy and Clinical Immunology·Jean-Christoph CaubetPhilippe A Eigenmann
Dec 16, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I DoñaG Canto
Dec 31, 2010·BMC Public Health·Ray B JonesEdward R Kaminski
Oct 11, 2011·The Journal of Allergy and Clinical Immunology·Andreas J Bircher, Kathrin Scherer Hofmeier
Jun 26, 2012·The Journal of Allergy and Clinical Immunology·Patrizia BonadonnaMauro Pagani
Nov 10, 2012·The British Journal of Dermatology·A BarbaudUNKNOWN Toxidermies group of the French Society of Dermatology
Apr 23, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Blanca-LópezM J Torres
Nov 6, 2013·The Journal of Allergy and Clinical Immunology·Eric Macy, Richard Contreras
Apr 3, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Polliana Mihaela Leru
Apr 5, 2014·Allergy·P DemolyB Y- H Thong
Apr 20, 2014·Irish Journal of Medical Science·N P ConlonC Lee-Brennan
Apr 9, 2015·Family Practice·Odette A E SaldenBerna D L Broekhuizen
May 2, 2015·The Journal of Allergy and Clinical Immunology·Antonino RomanoDonato Quaratino
Sep 30, 2015·Allergy·Eva GomesUNKNOWN ENDA/EAACI Drug Allergy Interest Group
Mar 19, 2016·Allergy·C MayorgaUNKNOWN In vitro tests for Drug Allergy Task Force of EAACI Drug Interest Group
Oct 8, 2016·Immunology and Allergy Clinics of North America·Donald D Stevenson, Andrew A White
Dec 14, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Elissa M AbramsAlexander G Singer
Jan 23, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Kimberly G BlumenthalLi Zhou

❮ Previous
Next ❯

Citations

Feb 9, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lucia DiaferioDavide Caimmi
Jun 24, 2019·Allergy·Paolo Maria MatricardiIoana Agache
Mar 7, 2021·BMJ Case Reports·Joana Carvalho, Georgeta Oliveira
May 18, 2021·Frontiers in Pharmacology·Abdelbaset A Elzagallaai, Michael J Rieder
Jun 19, 2021·Pediatric Allergy, Immunology, and Pulmonology·Ariana TelesTeresa Vieira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Marina Atanaskovic-MarkovicJean-Christoph Caubet
Current Allergy and Asthma Reports
Brett L Buchmiller, D A Khan
© 2022 Meta ULC. All rights reserved