An early development defect in the cerebral cortex of the reeler mouse. A morphological study leading to a hypothesis concerning the action of the mutant gene

Anatomy and Embryology
A M Goffinet

Abstract

Brains of reeler and normal mouse embryos have been studied on semi-thin sections and with Golgi impregnations. No change can be seen in the neuroepithelium or in the primary cortical organization. The first evidence of a morphological abnormality appears at E 14, in the cortical plate. Instead of being closely packed and radially oriented, nerve cells are loosely arranged and show quite variable orientations of their long axis and apical dendrite. The axons run obliquely through the cortical plate and do not display the characteristic angular course seen in the normal animal. It is suggested that the primary defect in reeler mice may be in the plasma membrane of cortical plate cells, resulting in a loss of their capacity for mutual recognition and binding. This could account for the cytoarchitectonic disorganization in this mutant, especially the absence of a molecular layer and the inversion of the histogenetic gradient in the developing cerebral cortex.

References

Nov 2, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MarianiC Sotelo
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·U RutishauserG M Edelman
Jan 1, 1978·Developmental Neuroscience·J M Lauder, H Krebs
Jan 1, 1978·Advances in Comparative Physiology and Biochemistry·J L Denburg
Mar 1, 1979·Nature·W G Quinn, J L Gould
Jan 1, 1978·Annual Review of Neuroscience·V S Caviness, P Rakic
Jan 5, 1979·Journal of Molecular Biology·R S MorganJ M McAdon
Sep 1, 1979·Neuroscience Letters·A M Goffinet, G Lyon
Feb 20, 1978·Anatomy and Embryology·M Marin-Padilla
Jun 15, 1978·The Journal of Comparative Neurology·G M Shoukimas, J W Hinds
Sep 27, 1978·Anatomy and Embryology·E Raedler, A Raedler
Feb 15, 1977·The Journal of Comparative Neurology·F L Rice, H Van der Loos
Dec 25, 1976·The Journal of Comparative Neurology·V S Caviness
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·J W Hinds, T L Ruffett
Jan 15, 1973·The Journal of Comparative Neurology·V S Caviness, R L Sidman
Jun 1, 1970·The Journal of Comparative Neurology·M Shimada, J Langman
Jun 1, 1970·The Journal of Comparative Neurology·J B Angevine
Mar 1, 1968·The Anatomical Record·S P Hicks, C J D'Amato
Sep 1, 1976·Neuroscience Letters·V S CavinessN L Hayes
Dec 1, 1977·Neuroscience Letters·D A Steindler

❮ Previous
Next ❯

Citations

Apr 24, 2015·Frontiers in Cellular Neuroscience·Chan Choo Yap, Bettina Winckler
Aug 25, 2001·Annual Review of Neuroscience·D S Rice, T Curran
Apr 22, 2009·Development, Growth & Differentiation·Yu Katsuyama, Toshio Terashima
Jan 22, 2011·Neurochemical Research·Takao HondaKazunori Nakajima
Jan 14, 2010·Development, Growth & Differentiation·Hideyuki DekimotoYu Katsuyama
Oct 15, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Hossein Fatemi
Sep 23, 2014·Frontiers in Pediatrics·Caterina MichettiMaria Luisa Scattoni
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E I Rugarli, A Ballabio
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·K NakajimaM Ogawa
Oct 10, 1997·Journal of Neurobiology·K E Hunter-Schaedle
May 24, 2013·PloS One·Emilia RomanoMaria Luisa Scattoni
Dec 30, 2011·Histochemistry and Cell Biology·Linus A VölkerAndreas Kispert
Dec 12, 2012·Genetic Testing and Molecular Biomarkers·Jyoti Rajan SharmaLize van der Merwe
Jun 5, 2003·Nature Reviews. Neuroscience·Fadel Tissir, André M Goffinet
Mar 8, 2006·Development Genes and Evolution·Arianna CostagliMarina Mione
Jul 4, 1998·Brain Research. Brain Research Reviews·T Curran, G D'Arcangelo
Jun 29, 2001·Mechanisms of Development·C Lambert de Rouvroit, A M Goffinet
Feb 15, 2003·Brain Research. Developmental Brain Research·Juan M LuqueAlfonso Fairén
Jan 22, 1988·The Journal of Comparative Neurology·G J Blatt, L M Eisenman
Jan 22, 1989·The Journal of Comparative Neurology·J A HeckrothL M Eisenman
Oct 8, 1986·The Journal of Comparative Neurology·T TerashimaK Mikoshiba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.