PMID: 8961127Sep 1, 1996Paper

An early rise in urine N-telopeptide predicts the growth response of normal prepubertal short children to growth hormone therapy

Journal of Pediatric Endocrinology & Metabolism : JPEM
M PhillipD Weber

Abstract

The effects of growth hormone (GH) therapy on biochemical markers of bone turnover were investigated in 11 short prepubertal children without GH deficiency by measuring serum osteocalcin, a marker for bone formation, and urinary concentrations of pyridinium cross-linked amino acids of collagen (PCL), and the peptide-bound pyridinoline residue N-telopeptide (NT), which are specific markers for bone resorption. GH treatment for three months increased bone turnover in this group of children: urinary PCL concentrations increased from 69 +/- 6.2 to 114 +/- 9.3 nmol/mmol Cr (p < 0.01), and urinary NT levels increased from 512 +/- 65 to 766 +/- 74 pmol BCE/mumol Cr (p = 0.058). Serum osteocalcin concentrations increased from 13.64 +/- 2.57 ng/ml to 26.45 +/- 1.39 ng/ml (p < 0.01). The increment in 12-hour urinary concentrations of PCL was highly correlated with the increment in 12-hour urinary NT levels (r = 0.92, p < 0.01). Stepwise multiple regression analysis revealed that the urinary concentrations of NT after 3 months of GH therapy were the best predictor of growth after 12 months of treatment (r = 0.78, F = 7.9, p = 0.037).

References

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Citations

Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Warren G Foster
Sep 15, 2004·Environmental Health : a Global Access Science Source·Eduardo Salazar-MartinezMauricio Hernandez-Avila
Dec 12, 2012·Environmental Health : a Global Access Science Source·Jaime MendiolaAlberto M Torres-Cantero
Apr 19, 2007·Paediatric and Perinatal Epidemiology·S Patricia Romano-RiquerMatthew P Longnecker
Feb 6, 2017·International Journal of Pediatric Endocrinology·Serwah Bonsu Asafo-AgyeiSamuel Blay Nguah
Nov 22, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Gülnur ÖzgünerEsra Koyuncu
Jun 19, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Melissa A ParisiRoberta A Pagon
Jan 10, 2013·Korean journal of urology·Joong Ho LeeSungchan Park
Jul 13, 2006·Der Urologe. Ausg. A·H A G Bosinski
Feb 12, 2004·Pediatric Transplantation·Philip D Acott, Jeffrey M Pernica
Dec 30, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·A SartorioG I Baroncelli
Mar 14, 2014·Paediatrics and International Child Health·Bhanu Kiran BhakhriVikram Datta
Sep 24, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Peter A Lee, Christopher P Houk
May 10, 2016·Indian Pediatrics·Rakesh MondalRupa Biswas

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