An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility

Pediatrics
S U SariciSule Yiğit

Abstract

In the era of early discharge of newborns from the hospital, newborns with ABO incompatibility are at especially greater risk for developing a subsequent significant hyperbilirubinemia because some of these infants also may present with some degree of ABO isoimmune disease. In this study, we aimed to determine prospectively the critical serum total bilirubin level to predict significant hyperbilirubinemia and severe hemolytic disease in healthy term newborns with ABO incompatibility based on a serum bilirubin measurement made at a postnatal age at which all newborns are at the hospital before discharge and at which any therapeutic intervention, if necessary, could be started as early as possible. A total of 136 healthy term newborns with ABO (O-A or O-B) blood group incompatibility were followed prospectively with daily serum total bilirubin measurements for the first 5 days of life. Newborns with serum total bilirubin levels of > or =5 mg/dL and an increase in serum total bilirubin concentration of >0.5 mg/dL/h in the first 24 hours, > or =12 mg/dL on day 2, > or =15 mg/dL on day 3, and > or =17 mg/dL on days 4 and 5 were defined to have significant hyperbilirubinemia and were started on phototherapy treatment. Additional trea...Continue Reading

References

Jan 1, 1989·American Journal of Diseases of Children·P D ConradA A Rosenberg
Jul 1, 1985·Clinical Pediatrics·D H Levine, H B Meyer
Mar 1, 1981·Acta paediatrica Scandinavica·J Whyte, H Graham
Nov 1, 1995·The Journal of Pediatrics·K S LeeT To
Apr 1, 1996·Archives of Pediatrics & Adolescent Medicine·E I SoskolneA Schork
Jun 2, 1998·Pediatrics·M J Maisels, E Kring
Aug 26, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·M McDonnellS P Devane
Dec 11, 1999·Archives of Pediatrics & Adolescent Medicine·J Grupp-PhelanR L Davis
Jan 25, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·D S SeidmanR Gale
Mar 24, 2000·Journal of Tropical Pediatrics·S U SariciE Gökçay

❮ Previous
Next ❯

Citations

Mar 13, 2008·Indian Journal of Pediatrics·Y Ramesh Bhat, Amitha Rao
Jun 9, 2009·Journal of Tropical Pediatrics·S Umit Sarici
Sep 10, 2005·Journal of Paediatrics and Child Health·Dorothy Dinesh
Mar 21, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·D TurnerM S Schimmel
Jun 19, 2013·World Journal of Pediatrics : WJP·Ramesh Y Bhat, Pavan C G Kumar
Jul 22, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Hakam YaseenMaha Darwich
Mar 24, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·R Shahid, S Graba
Jan 22, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jana Lozar-KrivecDarja Paro-Panjan
Jan 15, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·D L SchutzmanR J Wong
Apr 15, 2016·Paediatrics and International Child Health·Melissa C MorganTheodore D Ruel
Nov 21, 2008·Journal of Clinical Laboratory Analysis·Alpay CakmakOzcan Erel
Oct 21, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Ayşin NalbantoğluBurçin Nalbantoğlu
Jun 29, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Osman OztekinNihal Oygur
Dec 2, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ilke Ozahi IpekRabia Gönül Sezer
Apr 7, 2015·Paediatrics and International Child Health·Melissa C MorganTheodore D Ruel
Nov 16, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hülya HalisErol Ömer Atalay
Jul 26, 2018·Journal of Pediatric Hematology/oncology·Ryan A MetcalfMonica B Pagano
May 19, 2012·Paediatrics and International Child Health·Y R Bhat, C G Pavan Kumar
Dec 5, 2003·Pediatrics·Michael Kaplan, Cathy Hammerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.