An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

Chemical Communications : Chem Comm
Shengke LiRuibing Wang

Abstract

We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.

References

Jan 14, 2000·Journal of Medicinal Chemistry·W LeeS Mobashery
Dec 1, 2007·Journal of Environmental Monitoring : JEM·Kevin V ThomasKatherine H Langford
Sep 12, 2008·Macromolecular Bioscience·Nicolas PasquierRegine Willumeit
Jun 30, 2009·Environmental Pollution·Jose Luis Martinez
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Julian Davies, Dorothy Davies
Sep 21, 2010·Current Opinion in Microbiology·Gerard D Wright
Apr 26, 2013·Chemical Reviews·Wiktor SzymańskiBen L Feringa
Jun 28, 2013·Angewandte Chemie·Kai LiuXi Zhang
Oct 25, 2013·Nature Chemistry·Willem A VelemaBen L Feringa
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D G Joakim Larsson
Jul 22, 2015·Colloids and Surfaces. B, Biointerfaces·Tomasz KrukPiotr Warszyński
Aug 27, 2015·Angewandte Chemie·Haotian BaiShu Wang
Nov 14, 2015·Chemical Reviews·Steven J BarrowOren A Scherman
Jun 18, 2016·Chemistry : a European Journal·Haotian BaiShu Wang

❮ Previous
Next ❯

Citations

Nov 9, 2017·Chemistry : a European Journal·Anzhela GalstyanUlrich Dobrindt
Sep 1, 2018·Small·Hua ZouXia Wang
Feb 24, 2019·Pharmaceutics·Nadezhda KnauerEvgeny Apartsin
Oct 2, 2019·Frontiers in Chemistry·Debapratim DasWerner M Nau
Dec 12, 2018·Advanced Materials·Xingshu LiXi Zhang
Oct 31, 2019·Chemical Communications : Chem Comm·Yuchong YangXi Zhang
Nov 7, 2019·Chemical Communications : Chem Comm·Bohan TangXi Zhang
Jun 3, 2021·Nanomaterials·Alina AktanovaVladimir Kozlov
Jun 15, 2021·RSC Medicinal Chemistry·Zeyu WangRuibing Wang
Jan 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Mei LiuBaoxin Li
Aug 6, 2019·ACS Applied Materials & Interfaces·Yuan-Fu DingRuibing Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.