PMID: 9540936Apr 16, 1998Paper

An economic evaluation of first-trimester genetic sonography for prenatal detection of Down syndrome

Obstetrics and Gynecology
A M VintzileosT Beazoglou

Abstract

To determine 1) the diagnostic accuracy requirements of first-trimester genetic sonography from the cost-benefit point of view and 2) the economic impact of first-trimester genetic sonography for the United States on the basis of the accuracy of previously published studies. A cost-benefit equation was developed on the basis of the hypothesis that the cost of chorionic villus sampling (CVS) in pregnant women with advanced maternal age (at least 35 years old) should be at least equal to the cost of genetic sonography with CVS used only for those with abnormal ultrasound results. The components of the equation included the diagnostic accuracy of genetic ultrasound (sensitivity and specificity for detecting Down syndrome), the costs of the CVS package and genetic ultrasound, and the lifetime cost of Down syndrome cases. First-trimester genetic sonography was found to be beneficial if the overall sensitivity for detecting Down syndrome was greater than 70%, and even then, the cost-benefit ratio depended on the corresponding false-positive rate. The required minimum ultrasound sensitivity varied according to the maternal age-specific prevalence of Down syndrome and ranged between 40% (for women 35 years old) to 96% (for women 44 yea...Continue Reading

References

Mar 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J SzabóG Szemere
Jan 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C ComasA Fortuny
Jan 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B BrambatiG Zuliani
Sep 1, 1994·British Journal of Obstetrics and Gynaecology·K H NicolaidesR J Snijders
Nov 1, 1995·Fetal Diagnosis and Therapy·R J SnijdersK H Nicolaides
Mar 1, 1996·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R J SnijdersK H Nicolaides

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Citations

Nov 4, 1998·Seminars in Roentgenology·M Jackson, N C Rose
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Anthony M Vintzileos, Tryfon Beazoglou
Feb 15, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Tracy RobertsJo Garcia

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