PMID: 640745Jan 1, 1978Paper

An effect of actin on cell migration

International Archives of Allergy and Applied Immunology
T AkogluE J Holborow

Abstract

A specific inhibitory effect on mononuclear cell migration by smooth muscle actin and skeletal muscle actin is reported. Actin aged at 4 degrees C or heated at 56 degrees C for 10 min had little or no effect, but papain-denatured actin had a strong inhibitory action. Actin and/or its breakdown product(s) may interfere with mononuclear cell movement in vivo in pathological conditions where release of actin from damaged or dead cells occurs.

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