An effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cement

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Guan-Ming KuangHaobo Pan

Abstract

Strontium (Sr) plays a special role in enhancing the biological osteo-stimulation of calcium phosphate cement (CPC), not only increasing osteoblast-related gene expression and the alkaline phosphatase (ALP) activity of mesenchymal stem cells (MSCs), but also inhibiting the differentiation of osteoclasts. However, the incorporation of Sr unfortunately delays the setting of CPC and weakens its mechanical properties. The purpose of this study was to overcome the aforementioned problems by introducing a chelate reaction between Ca/Sr cations from the original solid phases and carboxyl groups from the liquid phases. As expected, the setting process of Sr-incorporated CPC was optimized and the cement body after rapid hardening was mostly consisting of unreacted original solid phases. After soaking in simulated body fluid for 14 and 28 days, the composition of the cement body gradually converted to the most thermodynamic stable phase, hydroxyapatite, indicating an in vitro bioactivity. The compressive strength was not impaired in the Sr-incorporated groups, but rather, further increased over time. Higher cell proliferation rate and better ALP activity of MG-63 cells cultured on the cement surface were obtained with the presence of Sr ...Continue Reading

References

Apr 1, 1997·Journal of Dental Research·M P GinebraJ A Planell
Feb 27, 1999·Biomaterials·I KhairounR Wenz
Oct 11, 2001·Journal of Endodontics·A M CherngS Takagi
Apr 9, 2002·Clinical Orthopaedics and Related Research·Racquel Zapanta LeGeros
Aug 15, 2002·European Journal of Pharmacology·Roland Baron, Yannis Tsouderos
Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N TakahashiT Suda
Mar 27, 2004·Metabolism: Clinical and Experimental·A BarbaraP J Marie
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·M TakechiK Suzuki
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·I KhairounJ A Planell
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·M BohnerJ Lemaitre
Nov 2, 2004·Journal of Materials Science. Materials in Medicine·A GisepB Rahn
Jan 25, 2005·Biomaterials·Dagang GuoYong Han
Jul 8, 2005·Biomaterials·Jean-Philippe St-PierreMaryam Tabrizian
Oct 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Jul 29, 2006·The Journal of the American Dental Association·Hockin H K XuJames H Yen
Sep 9, 2006·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Alberto J Ambard, Leonard Mueninghoff
Jul 25, 2007·Journal of Biomedical Materials Research. Part a·S PanzavoltaA Bigi
Sep 1, 2007·The Journal of the American Academy of Orthopaedic Surgeons·David J Hak
Sep 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Dukić-OttC Vervaet
Nov 14, 2008·Chemical Reviews·Racquel Zapanta LeGeros
Jan 13, 2009·Acta Biomaterialia·H B PanW W Lu
Mar 14, 2009·Dental Materials Journal·L C Chow
May 25, 2010·Acta Biomaterialia·Haobo PanWilliam W Lu
Jun 25, 2010·European Cells & Materials·M Bohner

❮ Previous
Next ❯

Citations

Jan 31, 2014·Journal of Materials Science. Materials in Medicine·Xu CuiMohamed N Rahaman
Feb 10, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Li LiBing Li
Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Xu CuiMohamed N Rahaman
Feb 16, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tiancheng LvBing Li
Jul 25, 2019·Frontiers in Bioengineering and Biotechnology·Saeid KargozarFrancesco Baino
Jun 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Matthias Schumacher, Michael Gelinsky
Apr 6, 2021·Frontiers in Bioengineering and Biotechnology·Lijuan SunDagang Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.