An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens

Vaccine
Bei WangLung-Ji Chang

Abstract

Viral modification of dendritic cells (DCs) may deliver a "danger signal" critical to the hypo-reactive DCs in cancer patients. Using three highly differentially expressed hepatoma tumor-associated antigens (TAAs): stem cell antigen-2 (Sca-2), glycoprotein 38 (GP38) and cellular retinoic acid binding protein 1 (RABP1), we explored the therapeutic potential of the DCs modified with lentiviral vectors (LVs). Preventive and therapeutic injection of the LV-TAA-DC vaccine into tumor-bearing mice elicited a strong anti-tumor response and extended survival, which was associated with tumor-specific interferon-gamma and cytotoxic T cell responses. In vivo elimination of the LV-TAA-DCs by a co-expressed thymidine kinase suicide gene abrogated the therapeutic effect. The modification of DCs with LVs encoding multiple TAAs offers a great opportunity in cancer immunotherapy.

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Citations

Jun 15, 2014·Experimental and Molecular Pathology·Wei PengBangqing Yuan
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Barbara-ann GuinnAlbert B Deisseroth
Dec 12, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shuhong HanLung-Ji Chang
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Aug 15, 2020·Frontiers in Immunology·Lea Skak Filtenborg FrederiksenAneesh Thakur
Jun 13, 2020·Frontiers in Oncology·Hui ZhangLung-Ji Chang
Nov 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bianza Moise BakadiaGuang Yang
Apr 10, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hui ZhangHua Jiang
Nov 26, 2010·Journal of Immune Based Therapies and Vaccines·Shuhong HanLung-Ji Chang

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