An Effective Method to Identify Adolescent Generalized Anxiety Disorder by Temporal Features of Dynamic Functional Connectivity

Frontiers in Human Neuroscience
Zhijun YaoLingjiang Li

Abstract

Generalized anxiety disorder (GAD) is one of common anxiety disorders in adolescents. Although adolescents with GAD are thought to be at high risk for other mental diseases, the disease-specific alterations have not been adequately explored. Recent studies have revealed the abnormal functional connectivity (FC) in adolescents with GAD. Most previous researches have investigated the static FC which ignores the fluctuations of FC over time and focused on the structures of "fear circuit". To figure out the alterations of dynamic FC caused by GAD and the possibilities of dynamic FC as biomarkers, we propose an effective approach to identify adolescent GAD using temporal features derived from dynamic FC. In our study, the instantaneous synchronization of pairwise signals was estimated as dynamic FC. The Hurst exponent (H) and variance, indicating regularity and variable degree of a time series respectively, were calculated as temporal features of dynamic FC. By leave-one-out cross-validation (LOOCV), a relatively high accuracy of 88.46% could be achieved when H and variance of dynamic FC were combined as features. In addition, we identified the disease-related regions, including regions belonging to default mode (DM) and cerebellar ...Continue Reading

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Citations

Nov 5, 2019·Human Brain Mapping·Changhong LiDavid Elmenhorst
Jun 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hui Juan ChenFeng Chen
Oct 3, 2018·The Cerebellum·Kim van DunMario Manto
Aug 1, 2020·Frontiers in Human Neuroscience·Olga TymofiyevaTony T Yang
Oct 22, 2020·Journal of Attention Disorders·Yue YangBinrang Yang
Jan 15, 2021·Translational Psychiatry·Zhenfu WenMohammed R Milad
Dec 10, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qian CuiHuafu Chen

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Software Mentioned

LOOCV
LIBLINEAR
Statistical Parametric Mapping ( SPM8 )
Data Processing Assistant Resting - State fMRI ( DPARSFA
GIFT
MATLAB
3DDESPIKE

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