An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

ELife
Yasin F DagdasTolga O Bozkurt

Abstract

Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

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Citations

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Datasets Mentioned

BETA
KR021366
KR021365

Methods Mentioned

BETA
isothermal titration calorimetry
immunoprecipitation
Transmission electron microscopy
pulldowns
coimmunoprecipitations
immunoprecipitation assay
co-IP
Co-IPs
confocal microscopy
gel filtration

Software Mentioned

Leica LAS AF
StatPlus LE
Adobe PHOTOSHOP CS5
MEGA5
ImageJ
ClustalW
BLASTP
iLIR
MicroCal Origin
Clustal X

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