An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging

Angewandte Chemie
Benhao LiFan Zhang

Abstract

A small-molecule fluorophore FD-1080 with both excitation and emission in the NIR-II region has been successfully synthesized for in vivo imaging. A heptamethine structure is designed to shift the absorption and emission into NIR-II region. Sulphonic and cyclohexene groups are introduced to enhance its water solubility and stability. The quantum yield of FD-1080 is 0.31 %, and can be increased to 5.94 % after combining with fetal bovine serum (FBS). Significantly, 1064 nm NIR-II excitation was demonstrated with the high tissue penetration depth and superior imaging resolution compared to previously reported NIR excitation from 650 nm to 980 nm. FD-1080 is not only capable of realizing non-invasive high-resolution deep-tissue hindlimb vasculature and brain vessel bioimaging, but also quantifying the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse.

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Citations

Apr 27, 2019·Advanced Materials·Shoujun ZhuHongjie Dai
May 17, 2019·Advanced Healthcare Materials·Mengyao ZhaoFan Zhang
Dec 4, 2019·Advanced Healthcare Materials·Hui ZhouXuechuan Hong
Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Jan 8, 2020·The Analyst·Yihan WangXuemei Wang
Feb 29, 2020·Future Medicinal Chemistry·Tao JiangWei Wang
Mar 20, 2020·Molecular Oncology·Xiao ZhangXiaoli Lan
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jorge H S K Monteiro
Oct 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenkun HanWenjing Tian
Nov 18, 2018·Chemical Society Reviews·Yu CaiXiaochen Dong
Oct 3, 2019·Advanced Materials·Haile LiuXiao-Dong Zhang
Aug 24, 2019·Chemical Communications : Chem Comm·Lei BaiWei Huang
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rongrong ZhaoChusen Huang
Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yue SunPeter J Stang

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