An efficient aldol-type direct reaction of isatins with TMSCH2CN

Organic & Biomolecular Chemistry
V U Bhaskara RaoRavi P Singh

Abstract

Cesium fluoride catalyzed direct cyanomethylation of various isatins by using trimethylsilyl acetonitrile (TMSAN) as a nucleophile has been developed. The reaction has been explored for a number of isatins, with various substitutions on its aromatic ring. Further, the versatility of the reaction is demonstrated by converting the direct aldol adducts to the corresponding intermediates of natural products and medicinally important compounds.

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Citations

Mar 31, 2017·The Journal of Organic Chemistry·V U Bhaskara RaoRavi P Singh
Nov 22, 2018·The FEBS Journal·Kamalika BanerjeeBhyravabhotla Jayaram

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