An efficient and facile synthesis of deuterium-labeled anticancer agent bendamustine hydrochloride

Journal of Labelled Compounds & Radiopharmaceuticals
Baomin LiuYinsheng Zhang

Abstract

Bendamustine hydrochloride is an alkylating agent that was developed for the treatment of various human cancers. The stable isotope-labeled bendamustine was required to support clinic studies. An effective and operationally simple method for the synthesis of [D6 ] bendamustine hydrochloride was developed using DCl as a catalyst and D2 O as a deuterium source. Under the present condition, regioselectively deuterated bendamustine hydrochloride with high deuterium incorporation is achieved.

References

Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lorenzo M LeoniChristina C Niemeyer
Sep 2, 2008·Organic Letters·Andrew Martins, Mark Lautens
Apr 9, 2010·Cancer Chemotherapy and Pharmacology·Nishant Tageja, Jasdeepa Nagi
Aug 2, 2011·British Journal of Clinical Pharmacology·Reinout C A SchellekensJos G W Kosterink

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