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An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products

Bioorganic & Medicinal Chemistry Letters

Jun 27, 2015

Anna ChwialkowskaBarbara Nawrot

Abstract

An efficient approach for the desulfuration of C5-substituted 2-thiouridines (R5S2U) bound in the RNA chain exclusively to 4-pyrimidinone nucleoside (R5H2U)-containing RNA products is proposed. This post-synthetic transformation avoids the preparation of a suitably protected H2U phospho...read more

Mentioned in this Paper

Surface Enhanced Laser Desorption Ionization Mass Spectrometry
Solid-Phase Nucleotide Synthesis Techniques
Transfer RNA
Pyrimidones
Nucleosides
Thiouridine
Pyrimidinones
2-thiouridine
Potassium hydrogen persulfate
Congener
Paper Details
References

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products

Bioorganic & Medicinal Chemistry Letters

Jun 27, 2015

Anna ChwialkowskaBarbara Nawrot

PMID: 26112441

DOI: 10.1016/j.bmcl.2015.06.019

Abstract

An efficient approach for the desulfuration of C5-substituted 2-thiouridines (R5S2U) bound in the RNA chain exclusively to 4-pyrimidinone nucleoside (R5H2U)-containing RNA products is proposed. This post-synthetic transformation avoids the preparation of a suitably protected H2U phospho...read more

Mentioned in this Paper

Surface Enhanced Laser Desorption Ionization Mass Spectrometry
Solid-Phase Nucleotide Synthesis Techniques
Transfer RNA
Pyrimidones
Nucleosides
Thiouridine
Pyrimidinones
2-thiouridine
Potassium hydrogen persulfate
Congener

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