An efficient laboratory workflow for environmental risk assessment of organic chemicals

Chemosphere
Linyan ZhuStephan Küppers

Abstract

In this study, we demonstrate a fast and efficient workflow to investigate the transformation mechanism of organic chemicals and evaluate the toxicity of their transformation products (TPs) in laboratory scale. The transformation process of organic chemicals was first simulated by electrochemistry coupled online to mass spectrometry (EC-MS). The simulated reactions were scaled up in a batch EC reactor to receive larger amounts of a reaction mixture. The mixture sample was purified and concentrated by solid phase extraction (SPE) for the further ecotoxicological testing. The combined toxicity of the reaction mixture was evaluated in fish egg test (FET) (Danio rerio) compared to the parent compound. The workflow was verified with carbamazepine (CBZ). By using EC-MS seven primary TPs of CBZ were identified; the degradation mechanism was elucidated and confirmed by comparison to literature. The reaction mixture and one primary product (acridine) showed higher ecotoxicity in fish egg assay with 96 h EC50 values of 1.6 and 1.0 mg L(-1) than CBZ with the value of 60.8 mg L(-1). The results highlight the importance of transformation mechanism study and toxicological effect evaluation for organic chemicals brought into the environment s...Continue Reading

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Citations

Jan 18, 2016·Environmental Research·R Moreno-GonzálezV M León
Mar 8, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Stephan BroxThorsten Reemtsma
Dec 16, 2016·Environmental Science & Technology·Kelly G AukemaLawrence P Wackett
Apr 18, 2018·Journal of Separation Science·Feipeng DuanHongbin Xiao

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