An efficient synthesis of 2-benzoxepines from Morita-Baylis-Hillman adducts using heterogeneous recyclable catalysts

Chemical & Pharmaceutical Bulletin
Biswanath DasUpadhayula Suryanarayana Murty

Abstract

2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.

References

Jul 1, 1976·Journal of Medicinal Chemistry·K UenoW Tsukada
Nov 1, 1990·Journal of the American College of Cardiology·J J GenestM R Malinow
Jan 1, 1981·Journal of Medicinal Chemistry·R E TenBrinkM G Wendling
Jun 25, 2005·Bioorganic & Medicinal Chemistry·Kei ManabeShū Kobayashi

❮ Previous
Next ❯

Citations

Aug 26, 2010·Chemical Reviews·Deevi BasavaiahSatpal Singh Badsara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Dustin J MergottWilliam R Roush
© 2021 Meta ULC. All rights reserved