An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors

Bioorganic Chemistry
Md Shahidul IslamMinoru Yoshida

Abstract

SK-658 is a potent histone deacetylase (HDAC) inhibitor that showed higher activity than SAHA due to the presence of extended hydrophobic group. We designed and synthesized thioester and SS-hybrid bearing SK-658 analogs as HDAC inhibitors. All the compounds were active in nano molar range and showed higher inhibitory activity than SAHA and SK-658. Among these, disulfide compounds showed the highest activity.

References

Nov 19, 2010·Expert Review of Hematology·Jasmine ZainOwen A O'Connor

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Citations

Jun 19, 2016·European Journal of Medicinal Chemistry·Joëlle Roche, Philippe Bertrand

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