PMID: 10564Aug 1, 1976

An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris

Postgraduate Medical Journal
M B Comerford, E M Besterman

Abstract

Following an initial dose response study, metoprolol, a selective beta1-receptor blocking agent, was compared with equipotent dosages of propanolol in a double blind cross-over study, including exercise tolerance tests, on fourteen patients with angina pectoris. Long term therapy with metoprolol then followed until the seventy-second week. Patients performed 8% more total work on metoprolol with 15% more work recorded up to the onset of S-T depression, in comparison with propranolol. In the long term, ther was no significant difference in work performed when the daily dosage of metoprolol was changed from a q.i.d. to a b.d. regime. Metoprolol was shown to be an effective anti-anginal compound with good tolerance and safety, with gradual improvement in underlying myocardial ischaemia during long term treatment.

References

Apr 12, 1975·British Medical Journal·W O WindsorN H Dyer
Aug 21, 1975·The New England Journal of Medicine·L H Hartley
Feb 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·B AbladL Ek
Nov 9, 1974·British Medical Journal·R H FelixM G Dahl
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks

Citations

Aug 1, 1979·British Journal of Clinical Pharmacology·S B PearsonJ M Patrick
Nov 1, 1978·World Journal of Surgery·F D LoopD M Cosgrove
Jan 13, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Vitor K L TakahashiStephen H Tsang
Jul 1, 1983·British Journal of Clinical Pharmacology·H J JürgensenU Brodthagen

Related Concepts

Adrenergic beta-Antagonists
Angina Pectoris
Clinical Trials
Cardiopulmonary Exercise Test
Betalok
Dalzic
Propanolamines
Rexigen

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