An electrocardiographic, molecular and biochemical approach to explore the cardioprotective effect of vasopressin and milrinone against phosphide toxicity in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Abbas JafariMohammad Abdollahi

Abstract

The present study was conducted to identify the protective effect of vasopressin (AVP) and milrinone on cardiovascular function, mitochondrial complex activities, cellular ATP reserve, oxidative stress, and apoptosis in rats poisoned by aluminum phosphide (AlP). Rats were divided into five groups (n = 12) including control, AlP (12.5 mg/kg), AlP + AVP (2.0 Units/kg), AlP + milrinone (0.25 mg/kg) and AlP + AVP + milrinone. After treatment, the animals were connected to an electronic cardiovascular monitoring device to monitor electrocardiographic (ECG) parameter. Finally, oxidative stress biomarkers, mitochondrial complex activities, ADP/ATP ratio and apoptosis were evaluated on the heart tissues. Results indicated that AlP administration induced ECG abnormalities along with a decline in blood pressure and heart rate. AVP and milrinone significantly ameliorated these changes in all treated groups. Considerable protective effects on oxidative stress biomarkers, complex IV activity, ADP/ATP ratio and caspase-3 and -9 activities in treated groups were also found. These findings were supported by flow cytometry assay of cardiomyocytes. In conclusion, administration of AVP and milrinone, not only improve cardiovascular functions in A...Continue Reading

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Citations

Jul 15, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Erdal UysalMehmet Karadag
Jul 11, 2018·Arhiv za higijenu rada i toksikologiju·Jafar AhmadiSomayyeh Karami-Mohajeri
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Nov 13, 2019·International Journal of Legal Medicine·Yue LiangYiwu Zhou
May 30, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Omid Mehrpour, Mohan Gurjar
Jun 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahedeh SamadiMohammad Abdollahi
Oct 30, 2021·Toxicology Mechanisms and Methods·Mohammad Reza Hooshangi ShayestehMohammad Abdollahi

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