PMID: 14415166Dec 1, 1959Paper

An electron microscope study of intranuclear inclusions in mouse liver and hepatoma

The Journal of Biophysical and Biochemical Cytology
E H LEDUC, J W WILSON

Abstract

An electron microscope study of intranuclear inclusions which occur in giant cells in a transplantable mouse hepatoma and in enlarged liver cells in mice fed a diet containing bentonite demonstrates that these inclusions are formed by invaginations of the nuclear envelope, and corroborates a previous histochemical study which revealed that the contents of the inclusions are of cytoplasmic origin. In the hepatoma cells the intranuclear inclusions are abundant, small, and situated close to the border of the nucleus, and there are wide openings from the cytoplasm into the invaginations whose contents include lipid droplets, ergastoplasm, and structurally normal mitochondria. In the enlarged liver cells the inclusions are fewer in number, generally much larger than those in the hepatoma, hence they extend deeper into the nucleus, and the interior is continuous with the cytoplasm through only a small opening. Some normal ergastoplasm is present within the inclusions but all other constituents are abnormal. Both normal and degenerating mitochondria occur in the cytoplasm but only degenerating ones are found within the inclusions. Both types of inclusions arise in greatly enlarged cells in which an attempt is made to maintain the norm...Continue Reading

References

Jul 25, 1956·The Journal of Biophysical and Biochemical Cytology·A B NOVIKOFFC DE DUVE
Jul 25, 1956·The Journal of Biophysical and Biochemical Cytology·W J FRAJOLAR G KLEINFELD
Mar 25, 1958·The Journal of Biophysical and Biochemical Cytology·D W FAWCETT, S ITO
Mar 25, 1958·The Journal of Biophysical and Biochemical Cytology·E DE HARVEN, C FRIEND
Oct 1, 1958·The Journal of Pathology and Bacteriology·J W WILSON, E H LEDUC
Jan 25, 1959·The Journal of Biophysical and Biochemical Cytology·M F BINGGELI

❮ Previous
Next ❯

Citations

Jan 1, 1962·Zeitschrift für Zellforschung und mikroskopische Anatomie·H S JOHNSTON
Jan 1, 1971·Virchows Archiv. A: Pathology. Pathologische Anatomie·Z SchaffL Sáfrány
Jan 1, 1990·Experimental Pathology·J Güttner
Aug 1, 1997·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·K DoiA Yasoshima
May 7, 2011·Diagnostic Cytopathology·Sandeep Kumar Arora, Pranab Dey
Jul 1, 1986·Journal of Comparative Pathology·B W FenwickN East
Jan 1, 1980·Medical Hypotheses·B A Young, G R Dickson
Oct 1, 1966·Experimental and Molecular Pathology·R J Stenger, D B Confer
Jul 1, 1964·Journal of Dental Research·G G ROSEC M POMERAT
Aug 1, 1963·Cancer·H R HELLSTROM, E R FISHER
Jun 1, 1981·Journal of Applied Toxicology : JAT·J S LeeA A Seawright
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A G SmithD Dinsdale
Sep 1, 1972·The American Journal of Anatomy·I Nakayama, P A Nickerson
Jan 1, 1962·The American Journal of Anatomy·W ANDREW
Mar 13, 2019·The Journal of Pathology. Clinical Research·Suzan SchwertheimHideo A Baba
Jun 15, 1964·Experientia·H W Altmann, J Haubrich
Oct 8, 2020·Scientific Reports·Suzan SchwertheimHideo Andreas Baba
Jul 1, 1960·The American Journal of Medicine·A B NOVIKOFF, E ESSNER
Oct 1, 1968·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B Flaks
Aug 1, 1970·Journal of Ultrastructure Research·H C Aldrich, I K Vasil
Mar 1, 1973·Journal of Ultrastructure Research·S Karasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.