PMID: 708267Jan 1, 1978Paper

An electron microscopic study of the surface structures and hemadsorption on chick embryo cells infected with rabies virus

Archives of Virology
N MinamotoI Yamamoto


Characteristic alterations at the surface of chick embryo cells infected with the HF-TC strain of rabies virus and the binding sites of hemadsorption were studied employing both scanning and transmission electron microscopes. The initial alteration of the cell surface structure revealed by scanning electron microscopy was an appearance of elongated and reticulated microvilli on the 2nd day after virus inoculation. On the 3rd day, numerous bullet-shaped virions could be seen budding as single, tetrapod-like structures and as radial projections both from the perikarya and microvilli. Thereafter, elongation of microvilli, formation of numerous blebs in various sizes, disappearance of filopodia, and rounding up of infected cells were observed as characteristic cytopathic effects by rabies virus infection. The attachments of goose erythrocytes to the infected cells occured in two forms. The one was adsorption of erythrocytes to the cell surface involving microvilli and filopodia in the absence of detectable virus, and the other was adsorptio n of erythrocytes to the virus particles budding from cell surface. The former could be seen from the early stage of infection through the end of observation period, while the latter was observe...Continue Reading


Apr 1, 1976·Japanese Journal of Medical Science & Biology·T Miyamura
Dec 1, 1975·Japanese Journal of Microbiology·K Amako
Oct 1, 1972·Journal of Ultrastructure Research·S K VernonB A Rubin
Feb 1, 1967·Journal of Virology·K HummelerT J Wiktor
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT


Jun 1, 1988·Epidemiology and Infection·N MinamotoY Suzuki
Nov 6, 2003·The Journal of Veterinary Medical Science·Makoto SugiyamaN Minamoto

Related Concepts

Plasma Membrane
Electron Microscopy
Rabies virus

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